Hackl, Christina and Schlitt, Hans J. and Kirchner, Gabriele I. and Knoppke, Birgit and Loss, Martin (2014) Liver transplantation for malignancy: current treatment strategies and future perspectives. WORLD JOURNAL OF GASTROENTEROLOGY, 20 (18). pp. 5331-5344. ISSN 1007-9327, 2219-2840
Full text not available from this repository. (Request a copy)Abstract
In 1967, Starzl et al performed the first successful liver transplantation for a patient diagnosed with hepatoblastoma. In the following, liver transplantation was considered ideal for complete tumor resection and potential cure from primary hepatic malignancies. Several reports of liver transplantation for primary and metastatic liver cancer however showed disappointing results and the strategy was soon dismissed. In 1996, Mazzaferro et al introduced the Milan criteria, offering liver transplantation to patients diagnosed with limited hepatocellular carcinoma. Since then, liver transplantation for malignant disease is an ongoing subject of preclinical and clinical research. In this context, several aspects must be considered: (1) Given the shortage of deceased-donor organs, long-term overall and disease free survival should be comparable with results obtained in patients transplanted for nonmalignant disease; (2) In this regard, living-donor liver transplantation may in selected patients help to solve the ethical dilemma of optimal individual patient treatment vs organ allocation justice; and (3) Ongoing research focusing on perioperative therapy and antiproliferative immunosuppressive regimens may further reduce tumor recurrence in patients transplanted for malignant disease and thus improve overall survival. The present review gives an overview of current indications and future perspectives of liver transplantation for malignant disease. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATIC EPITHELIOID HEMANGIOENDOTHELIOMA; LONG-TERM SURVIVAL; METASTATIC NEUROENDOCRINE TUMORS; SOLID-ORGAN TRANSPLANTATION; PEDIATRIC-ONCOLOGY SIOP; BODY RADIATION-THERAPY; HEPATOCELLULAR-CARCINOMA; DONOR LIVER; HILAR CHOLANGIOCARCINOMA; WAITING-LIST; Hepatocellular; Fibrolamellar; Carcinoma; Cholangiocellular; Hepatoblastoma; Liver metastases |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Nov 2019 13:22 |
| Last Modified: | 08 Nov 2019 13:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10183 |
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