Kabesch, Michael (2014) Epigenetics in asthma and allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14 (1). pp. 62-68. ISSN 1528-4050, 1473-6322
Full text not available from this repository. (Request a copy)Abstract
Purpose of reviewEpigenetic mechanisms such as DNA methylation, histone modification and microRNA control the accessibility of the genome and manage gene transcription in response to the environment in a heritable fashion. Recent evidence suggests that these mechanisms play a role in allergy and asthma.Recent findingsHere, we give an overview on recent developments in the field of asthma and allergy epigenetics with a special focus on the role of DNA methylation in these diseases, where finally, first pilot studies investigating differences in methylation pattern in patients have been published. Although these studies have to be interpreted with caution, it seems that methylation is affected by environmental stimuli such as prenatal smoke exposure and farming environments, whereas asthma status is associated with change in methylation in early childhood.SummaryEarly stage data from population studies indicate a role of methylation differences in asthma and allergy, whereas the exact impact of these epigenetic mechanisms on disease development needs to be elucidated further.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DNA METHYLATION; CHILDHOOD ASTHMA; CELL-DIFFERENTIATION; GENE-EXPRESSION; CYTOKINE GENES; PATTERNS; EXPOSURE; DISEASE; PERSPECTIVE; 17Q12-Q21; allergy; asthma; epigenetics; methylation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Jul 2020 10:17 |
| Last Modified: | 21 Jul 2020 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10693 |
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