Seliger, Corinna and Schaertl, Julia and Gerken, Michael and Luber, Christian and Proescholdt, Martin and Riemenschneider, Markus J. and Leitzmann, Michael F. and Hau, Peter and Klinkhammer-Schalke, Monika (2018) Use of statins or NSAIDs and survival of patients with high-grade glioma. PLOS ONE, 13 (12): e0207858. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Background High-grade glioma (HGG) is associated with a limited prognosis. Drug repurposing has become of increasing interest to improve standard therapy. Statins and NSAIDs inhibit glioma cell growth in vitro and in vivo, but data on statin and NSAID treatment in relation to survival of patients with HGG are sparse. Methods We performed multivariable adjusted Cox-regression analyses among 1,093 patients with HGG from a regional cancer registry to obtain Hazard Ratios (HRs) with 95% Confidence Intervals (CIs) for overall survival (OS) and progression-free survival (PFS) according to treatment with statins or NSAIDs. Data on dose and duration of treatment was mostly lacking in our analysis, therefore we were not able to perform dose-response analyses. Results Use of statins was unrelated to OS or PFS of glioma patients. Use of aspirin was associated with prolonged OS and PFS in patients with WHO grade III, but not WHO grade IV glioma. Use of other NSAIDs (diclofenac, ibuprofen) or non-NSAID analgesics (paracetamol) was mostly unrelated to survival of glioma patients. Use of selective COX-2 inhibitors and metamizol was related to inferior patient survival in parts of the analyses. Conclusions Use of statins or NSAIDS, including aspirin, was not associated with prolonged OS or PFS of patients with WHO grade IV glioma in our selected cohort. There was an indication for improved survival in patients with WHO grade III glioma using aspirin, but further studies are needed to confirm our first observation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HUMAN GLIOBLASTOMA CELLS; LOW-DOSE ASPIRIN; NEWLY-DIAGNOSED GLIOBLASTOMA; PHASE-II; METRONOMIC CHEMOTHERAPY; VENOUS THROMBOEMBOLISM; ADJUVANT TEMOZOLOMIDE; CELECOXIB; PROLIFERATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2019 07:13 |
| Last Modified: | 04 Oct 2019 07:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13376 |
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