Linck, Lisa and Liebig, Janika and Voeller, Daniel and Eichner, Norbert and Lehmann, Gerhard and Meister, Gunter and Bosserhoff, Anja (2018) MicroRNA-sequencing data analyzing melanoma development and progression. EXPERIMENTAL AND MOLECULAR PATHOLOGY, 105 (3). pp. 371-379. ISSN 0014-4800, 1096-0945
Full text not available from this repository. (Request a copy)Abstract
MicroRNAs (miRNAs) deregulated in melanoma are of growing importance in cancer research. We aimed to define the miRNAome of melanoma cell lines and primary melanocytes by RNA-Seq using identical cell lines as in a published miRNA expression study based on eDNA arrays. We identified 79 miRNAs, which are significantly deregulated during melanoma development. In addition, we could also determine 29 miRNAs being involved in melanoma progression. Interestingly, not all characterized miRNAs derived from cDNA array analyses of our and other groups could be found to be differentially expressed using RNA-Seq analyses, however, new miRNAs, formerly not associated with melanoma, were found to be strongly regulated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARGONAUTE PROTEINS; CELL-PROLIFERATION; EXPRESSION; INVASION; PATHWAY; MIRNAS; Melanoma; microRNA; RNA-Seq |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2019 08:48 |
| Last Modified: | 04 Oct 2019 08:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13415 |
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