Renner, Kerstin and Metz, Sophia and Metzger, Anne-Mieke and Neumayer, Sophia and Schmidbauer, Kathrin and Talke, Yvonne and Buchtler, Simone and Halbritter, Dagmar and Mack, Matthias (2018) Expression of IL-3 receptors and impact of IL-3 on human T and B cells. CELLULAR IMMUNOLOGY, 334. pp. 49-60. ISSN 0008-8749, 1090-2163
Full text not available from this repository. (Request a copy)Abstract
A large number of animal models revealed that IL-3 plays an important role for the development of T and B cell-mediated autoimmune diseases. However, little is known about the expression and regulation of IL-3 receptors in human T and B cells and how IL-3 modulates the activation and survival of these cells. We show that the IL-3 receptor CD123 is substantially upregulated on proliferating CD4(+) and CD8(+) T as well as B cells. Upregulation of CD123 differs between various activators and can be further modulated by cytokines. Exposure of human T and B cells to IL-3 enhances proliferation and survival. IL-3 also induces a shift towards secretion of proinflammatory cytokines in T and B cells and reduces the expression of IL-10 in B cells. Thus IL-3 may have proinflammatory and immunostimulatory properties also in human autoimmune diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLONY-STIMULATING FACTOR; HUMAN RECOMBINANT IL-3; DENDRITIC CELLS; HUMAN BASOPHILS; MEDIATOR RELEASE; LUPUS NEPHRITIS; HUMAN MONOCYTES; INTERLEUKIN-3; RESPONSES; DIFFERENTIATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2019 09:58 |
| Last Modified: | 04 Oct 2019 09:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13435 |
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