Bohn, Toszka and Rapp, Steffen and Luther, Natascha and Klein, Matthias and Bruehl, Till-Julius and Kojima, Nobuhiko and Lopez, Pamela Aranda and Hahlbrock, Jennifer and Muth, Sabine and Endo, Shogo and Pektor, Stefanie and Brand, Almut and Renner, Kathrin and Popp, Vanessa and Gerlach, Katharina and Vogel, Dennis and Lueckel, Christina and Arnold-Schild, Danielle and Pouyssegur, Jacques and Kreutz, Marina and Huber, Magdalena and Koenig, Jochem and Weigmann, Benno and Probst, Hans-Christian and von Stebut, Esther and Becker, Christian and Schild, Hansjoerg and Schmitt, Edgar and Bopp, Tobias (2018) Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages. NATURE IMMUNOLOGY, 19 (12). 1319-+. ISSN 1529-2908, 1529-2916
Full text not available from this repository. (Request a copy)Abstract
Many tumors evolve sophisticated strategies to evade the immune system, and these represent major obstacles for efficient antitumor immune responses. Here we explored a molecular mechanism of metabolic communication deployed by highly glycolytic tumors for immunoevasion. In contrast to colon adenocarcinomas, melanomas showed comparatively high glycolytic activity, which resulted in high acidification of the tumor microenvironment. This tumor acidosis induced Gprotein-coupled receptor-dependent expression of the transcriptional repressor ICER in tumor-associated macrophages that led to their functional polarization toward a non-inflammatory phenotype and promoted tumor growth. Collectively, our findings identify a molecular mechanism of metabolic communication between non-lymphoid tissue and the immune system that was exploited by high-glycolytic-rate tumors for evasion of the immune system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SERUM LACTATE-DEHYDROGENASE; PROTEIN-COUPLED RECEPTORS; CAMP EARLY REPRESSOR; NF-KAPPA-B; LACTIC-ACID; INFLAMMATORY RESPONSES; SOLID TUMORS; IN-VITRO; IMMUNE; PROGRESSION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Oct 2019 06:55 |
| Last Modified: | 07 Oct 2019 06:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13463 |
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