Walters, Raymond K. and Polimanti, Renato and Johnson, Emma C. and McClintick, Jeanette N. and Adams, Mark J. and Adkins, Amy E. and Aliev, Fazil and Bacanu, Silviu-Alin and Batzler, Anthony and Bertelsen, Sarah and Biernacka, Joanna M. and Bigdeli, Tim B. and Chen, Li-Shiun and Clarke, Toni-Kim and Chou, Yi-Ling and Degenhardt, Franziska and Docherty, Anna R. and Edwards, Alexis C. and Fontanillas, Pierre and Foo, Jerome C. and Fox, Louis and Frank, Josef and Giegling, Ina and Gordon, Scott and Hack, Laura M. and Hartmann, Annette M. and Hartz, Sarah M. and Heilmann-Heimbach, Stefanie and Herms, Stefan and Hodgkinson, Colin and Hoffmann, Per and Hottenga, Jouke Jan and Kennedy, Martin A. and Alanne-Kinnunen, Mervi and Konte, Bettina and Lahti, Jari and Lahti-Pulkkinen, Marius and Lai, Dongbing and Ligthart, Lannie and Loukola, Anu and Maher, Brion S. and Mbarek, Hamdi and McIntosh, Andrew M. and McQueen, Matthew B. and Meyers, Jacquelyn L. and Milaneschi, Yuri and Palviainen, Teemu and Pearson, John F. and Peterson, Roseann E. and Ripatti, Samuli and Ryu, Euijung and Saccone, Nancy L. and Salvatore, Jessica E. and Sanchez-Roige, Sandra and Schwandt, Melanie and Sherva, Richard and Streit, Fabian and Strohmaier, Jana and Thomas, Nathaniel and Wang, Jen-Chyong and Webb, Bradley T. and Wedow, Robbee and Wetherill, Leah and Wills, Amanda G. and Boardman, Jason D. and Chen, Danfeng and Choi, Doo-Sup and Copeland, William E. and Culverhouse, Robert C. and Dahmen, Norbert and Degenhardt, Louisa and Domingue, Benjamin W. and Elson, Sarah L. and Frye, Mark A. and Gaebel, Wolfgang and Hayward, Caroline and Ising, Marcus and Keyes, Margaret and Kiefer, Falk and Kramer, John and Kuperman, Samuel and Lucae, Susanne and Lynskey, Michael T. and Maier, Wolfgang and Mann, Karl and Mannisto, Satu and Muller-Myhsok, Bertram and Murray, Alison D. and Nurnberger, John I. and Palotie, Aarno and Preuss, Ulrich and Raikkonen, Katri and Reynolds, Maureen D. and Ridinger, Monika and Scherbaum, Norbert and Schuckit, Marc A. and Soyka, Michael and Treutlein, Jens and Witt, Stephanie and Wodarz, Norbert and Zill, Peter and Adkins, Daniel E. and Boden, Joseph M. and Boomsma, Dorret I. and Bierut, Laura J. and Brown, Sandra A. and Bucholz, Kathleen K. and Cichon, Sven and Costello, E. Jane and De Wit, Harriet and Diazgranados, Nancy and Dick, Danielle M. and Eriksson, Johan G. and Farrer, Lindsay A. and Foroud, Tatiana M. and Gillespie, Nathan A. and Goate, Alison M. and Goldman, David and Grucza, Richard A. and Hancock, Dana B. and Harris, Kathleen Mullan and Heath, Andrew C. and Hesselbrock, Victor and Hewitt, John K. and Hopfer, Christian J. and Horwood, John and Iacono, William and Johnson, Eric O. and Kaprio, Jaakko A. and Karpyak, Victor M. and Kendler, Kenneth S. and Kranzler, Henry R. and Krauter, Kenneth and Lichtenstein, Paul and Lind, Penelope A. and McGue, Matt and MacKillop, James and Madden, Pamela A. F. and Maes, Hermine H. and Magnusson, Patrik and Martin, Nicholas G. and Medland, Sarah E. and Montgomery, Grant W. and Nelson, Elliot C. and Noethen, Markus M. and Palmer, Abraham A. and Pedersen, Nancy L. and Penninx, Brenda W. J. H. and Porjesz, Bernice and Rice, John P. and Rietschel, Marcella and Riley, Brien P. and Rose, Richard and Rujescu, Dan and Shen, Pei-Hong and Silberg, Judy and Stallings, Michael C. and Tarter, Ralph E. and Vanyukov, Michael M. and Vrieze, Scott and Wall, Tamara L. and Whitfield, John B. and Zhao, Hongyu and Neale, Benjamin M. and Gelernter, Joel and Edenberg, Howard J. and Agrawal, Arpana (2018) Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. NATURE NEUROSCIENCE, 21 (12). 1656-+. ISSN 1097-6256, 1546-1726
Full text not available from this repository. (Request a copy)Abstract
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 x 10(-13)) and African ancestries (rs2066702; P = 2.2 x 10(-9)). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, attention deficit-hyperactivity disorder, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; NATIONAL EPIDEMIOLOGIC SURVEY; LD SCORE REGRESSION; RISK; METAANALYSIS; HERITABILITY; CONSUMPTION; ADH1B; PARTICIPANTS; COMORBIDITY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Oct 2019 13:00 |
| Last Modified: | 07 Oct 2019 13:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13465 |
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