Martini, Thomas and Heinkele, Jakob and Mayr, Roman and Weis, Cleo-Aron and Wezel, Felix and Wahby, Sarah and Eckstein, Markus and Schnoller, Thomas and Breyer, Johannes and Wirtz, Ralph and Ritter, Manuel and Bolenz, Christian and Erben, Philipp (2018) Predictive value of lymphangiogenesis and proliferation markers on mRNA level in urothelial carcinoma of the bladder after radical cystectomy. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 36 (12): 530.e19. ISSN 1078-1439, 1873-2496
Full text not available from this repository. (Request a copy)Abstract
Objective: To evaluate the mRNA expression of lymphangiogenesis and proliferation markers and to examine its association with histopathological characteristics and clinical outcome in patients with urothelial carcinoma of the bladder (UCB) after radical cystectomy (RC). Patients and methods: Gene expression analysis of the vascular endothelial growth-C and-D (VEGF-C/-D), its receptor VEGF receptor-3 (VEGFR-3), MKI67, and RACGAP1 was performed in 108 patients after radical cystectomy and their correlation with clinical-pathological parameters was investigated. Uni- and multivariate regression analyses were used to identify predictors for cancer -specific survival (CSS), recurrence-free survival (RFS) and overall survival (OS) after RC. Results: The expression of RACGAP1 and VEGFR-3 showed an association with a higher pT stage (P = 0.049; P = 0.009). MKI67 showed an association with a high-grade urothelial carcinoma of the bladder (P = 0.021). VEGFR-3 expression was significantly associated with the presence of lymphovascular invasion (LVI) (P = 0.016) and lymph node metastases (pN+) (P = 0.028). With the univariate analysis, overexpression of VEGFR-3 (P = 0.029) and the clinical-pathological parameters pT stage (P < 0.0001), pN+ (P = 0.0004), LVI (P < 0.0001) and female gender (P = 0.021) were significantly associated with a reduced CSS. Multivariate analysis identified a higher pT stage (P = 0.017) and LVI (P = 0.008) as independent predictors for reduced CSS. Independent predictors for reduced OS were a higher pT stage (P = 0.0007) and LVI (P = 0.0021), while overexpression of VEGF-D was associated with better OS (P < 0.0001). Conclusions: The mRNA expression of the investigated markers showed associations with common histopathological parameters. Increased expression of VEGF-D is independently associated with better overall survival. (C) 2018 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; INDEPENDENT PREDICTOR; RACGAP1 EXPRESSION; CANCER PATIENTS; VEGF-D; KI67; NEOADJUVANT; RECURRENCE; MORTALITY; OUTCOMES; Lymph-specific marker; mRNA expression; Proliferation marker; Urothelial carcinoma of the bladder |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Oct 2019 13:32 |
| Last Modified: | 07 Oct 2019 13:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13476 |
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