Thamm, M. and Sturm, K. and Schlossmann, J. and Scheiner, R. (2018) Levels and activity of cyclic guanosine monophosphate-dependent protein kinase in nurse and forager honeybees. INSECT MOLECULAR BIOLOGY, 27 (6). pp. 815-823. ISSN 0962-1075, 1365-2583
Full text not available from this repository. (Request a copy)Abstract
Age-dependent division of labour in honeybees was shown to be connected to sensory response thresholds. Foragers show a higher gustatory responsiveness than nurse bees. It is generally assumed that nutrition-related signalling pathways underlie this behavioural plasticity. Here, one important candidate gene is the foraging gene, which encodes a cyclic guanosine monophosphate-dependent protein kinase (PKG). Several roles of members of this enzyme family were analysed in vertebrates. They own functions in important processes such as growth, secretion and neuronal adaptation. Honeybee foraging messenger RNA expression is upregulated in the brain of foragers. In vivo activation of PKG can modulate gustatory responsiveness. We present for the first time PKG protein level and activity data in the context of social behaviour and feeding. Protein level was significantly higher in brains of foragers than in those of nurse bees, substantiating the role of PKG in behavioural plasticity. However, enzyme activity did not differ between behavioural roles. The mediation of feeding status appears independent of PKG signalling. Neither PKG content nor enzyme activity differed between starved and satiated individuals. We suggest that even though nutrition-related pathways are surely involved in controlling behavioural plasticity, which involves changes in PKG signalling, mediation of satiety itself is independent of PKG.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIVISION-OF-LABOR; BEES APIS-MELLIFERA; DROSOPHILA-MELANOGASTER; SUCROSE RESPONSIVENESS; SPATIAL-EXPRESSION; NATURAL VARIATION; INSECT SOCIETIES; GENE-EXPRESSION; NITRIC-OXIDE; FOOD-INTAKE; honeybee; division of labour; sucrose responsiveness; foraging gene/PKG |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehreinheit Pharmakologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Oct 2019 06:04 |
| Last Modified: | 09 Oct 2019 06:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13493 |
Actions (login required)
 |
View Item |
