Schultz-Larsen, Torsten and Lenk, Andrea and Kalinowska, Kamila and Vestergaard, Lau Kraesing and Pedersen, Carsten and Isono, Erika and Thordal-Christensen, Hans (2018) The AMSH3 ESCRT-III-Associated Deubiquitinase Is Essential for Plant Immunity. CELL REPORTS, 25 (9). 2329-+. ISSN 2211-1247,
Full text not available from this repository. (Request a copy)Abstract
Plant "nucleotide-binding leucine-rich repeat'' receptor proteins (NLRs) detect alterations in host targets of pathogen effectors and trigger immune responses. The Arabidopsis thaliana mutant pen1 syp122 displays autoimmunity, and a mutant screen identified the deubiquitinase "associated molecule with the SH3 domain of STAM3'' (AMSH3) to be required for this phenotype. AMSH3 has previously been implicated in ESCRT-mediated vacuolar targeting. Pathology experiments show that AMSH3 activity is required for immunity mediated by the CC-NLRs, RPS2 and RPM1. Co-expressing the autoactive RPM1(D505V) and the catalytically inactive ESCRT-III protein SKD1(E232Q) in Nicotiana benthamiana supports the requirement of ESCRT-associated functions for this CC-NLR-activated immunity. Meanwhile, loss of ESCRT function in A. thaliana is lethal, and we find that AMSH3 knockout-triggered seedling lethality is "enhanced disease susceptibility 1'' (EDS1) dependent. Future studies may reveal whether AMSH3 is monitored by a TIR-NLR immunity receptor.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISEASE RESISTANCE; CELL-DEATH; SALICYLIC-ACID; SNARE-PROTEIN; ENZYME AMSH3; ARABIDOPSIS; GENE; RECOGNITION; DEFENSE; AUTOIMMUNITY; |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 580 Botanical sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften > Lehrstuhl für Zellbiologie und Pflanzenphysiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Oct 2019 06:11 |
| Last Modified: | 09 Oct 2019 06:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13517 |
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