Van Winkle, Jacob A. and Robinson, Bridget A. and Peters, A. Mack and Li, Lena and Nouboussi, Ruth V. and Mack, Matthias and Nice, Timothy J. (2018) Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells. CELL HOST & MICROBE, 24 (5): e4. 665-+. ISSN 1931-3128, 1934-6069
Full text not available from this repository. (Request a copy)Abstract
Viral persistence can contribute to chronic disease and promote virus dissemination. Prior work demonstrated that timely clearance of systemic murine norovirus (MNV) infection depends on cell-intrinsic type I interferon responses and adaptive immunity. We now find that the capsid of the systemically replicating MNV strain CW3 promotes lytic cell death, release of interleukin-1 alpha, and increased inflammatory cytokine release. Correspondingly, inflammatory monocytes and neutrophils are recruited to sites of infection in a CW3-capsid-dependent manner. Recruited monocytes and neutrophils are subsequently infected, representing a majority of infected cells in vivo. Systemic depletion of inflammatory monocytes or neutrophils from persistently infected Rag1(-/-) mice reduces viral titers in a tissue-specific manner. These data indicate that the CW3 capsid facilitates lytic cell death, inflammation, and recruitment of susceptible cells to promote persistence. Infection of continuously recruited inflammatory cells may be a mechanism of persistence broadly utilized by lytic viruses incapable of establishing latency.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NORWALK VIRUS; I INTERFERON; TRANSPLANT RECIPIENTS; CAPSID PROTEIN; INFECTION; RECEPTOR; REPLICATION; SUFFICIENT; TROPISM; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Oct 2019 06:45 |
| Last Modified: | 09 Oct 2019 06:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13538 |
Actions (login required)
 |
View Item |
