Verloh, Niklas and Einspieler, Ingo and Utpatel, Kirsten and Menhart, Karin and Brunner, Stefan and Hofheinz, Frank and van den Hoff, Joerg and Wiggermann, Philipp and Evert, Matthias and Stroszczynski, Christian and Hellwig, Dirk and Grosse, Jirka (2018) In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by F-18-FDG PET/CT. EJNMMI RESEARCH, 8: 98. ISSN 2191-219X,
Full text not available from this repository. (Request a copy)Abstract
ObjectiveThe aim of this study was to assess the value of F-18-FDG PET/CT for quantitative assessment of hepatic metabolism in patients with different stages of liver fibrosis/cirrhosis.Materials and methods(18)F-FDG PET/CT scans of 37 patients either with or without liver fibrosis/cirrhosis, classified according to the METAVIR score (F0-F4) obtained from histopathological analysis of liver specimen, were analyzed retrospectively and classified as follows: no liver fibrosis (F0, n=6), mild liver fibrosis (F1, n=11), advanced liver fibrosis (F2, n=6), severe liver fibrosis (F3, n=5), and liver cirrhosis (F4, n=11). The liver-to-blood ratio (LBR, scan time corrected for a reference time of 75min) was compared between patient groups.ResultsPatients with liver fibrosis or cirrhosis (F1; LBR 1.530.35) showed a significant higher LBR than patients with normal liver parenchyma (F0, 1.08 +/- 0.23; P=0.004). In direct comparison, LBR increased up to the advanced stage of liver fibrosis (F2; 2.00 +/- 0.40) and decreased until liver cirrhosis is reached (F4, 1.32 +/- 0.14).Conclusion Functional changes in liver parenchyma during liver fibrosis/cirrhosis affect hepatic glucose metabolism and significantly differ between stages of liver fibrosis/cirrhosis, classified according to the METAVIR scoring system, as demonstrated by LBR quantification by F-18-FDG PET/CT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STANDARD UPTAKE VALUES; FDG UPTAKE; EMISSION-TOMOGRAPHY; INSULIN-RESISTANCE; DYNAMIC PET; DISEASE; CIRRHOSIS; EXPRESSION; TRANSPORTER; FIBROSIS; F-18-FDG PET/CT; Hepatic metabolism; Liver fibrosis; Liver cirrhosis; FDG kinetics; METAVIR score |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Oct 2019 06:23 |
| Last Modified: | 10 Oct 2019 06:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13547 |
Actions (login required)
 |
View Item |
