Delcroix, Marion and Staehler, Gerd and Gall, Henning and Gruenig, Ekkehard and Held, Matthias and Halank, Michael and Klose, Hans and Vonk-Noordegraaf, Anton and Rosenkranz, Stephan and Pepke-Zaba, Joanna and Opitz, Christian F. and Gibbs, J. Simon R. and Lange, Tobias J. and Tsangaris, Iraklis and Huscher, Doerte and Pittrow, David and Olsson, Karen M. and Hoeper, Marius M. (2018) Risk assessment in medically treated chronic thromboembolic pulmonary hypertension patients. EUROPEAN RESPIRATORY JOURNAL, 52 (5): 1800248. ISSN 0903-1936, 1399-3003
Full text not available from this repository. (Request a copy)Abstract
Abbreviated versions of the risk stratification strategy of the European Society of Cardiology (ESC)/European Respiratory Society (ERS) pulmonary hypertension guidelines have been recently validated in patients with pulmonary arterial hypertension. We aimed to investigate their prognostic value in medically treated chronic thromboembolic pulmonary hypertension (CTEPH) patients from the COMPERA registry, which collects six variables of interest (World Health Organization Functional Class, 6-min walk distance, brain natriuretic peptide, right atrial pressure, cardiac index and mixed venous oxygen saturation). We included patients with at least one follow-up visit, no pulmonary endarterectomy and at least three of the six variables available, and classified the patients into low-, intermediate- and high-risk groups. As a secondary analysis, the number of noninvasive low-risk criteria was counted. The association between risk assessment and survival was evaluated. Data from inclusion and follow-up (median 7 months) visits were available for 561 and 231 patients, respectively. Baseline 1- and 5-year survival estimates were significantly different (p<0.0001) in the baseline low-risk (98.6% and 88.3%, respectively), intermediate-risk (94.9% and 61.8%, respectively) and high-risk (75.5% and 32.9%, respectively) cohorts. Follow-up data were even more discriminative, with 100%, 92% and 69% 1-year survival, respectively. The number of low-risk noninvasive criteria was also associated with survival. These analyses suggest that the ESC/ERS risk assessment may be applicable in patients with medically treated CTEPH.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PREDICTORS; RIOCIGUAT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Oct 2019 09:02 |
| Last Modified: | 10 Oct 2019 09:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13592 |
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