Emons, Guenter and Steiner, Eric and Vordermark, Dirk and Uleer, Christoph and Bock, Nina and Paradies, Kerstin and Ortmann, Olaf and Aretz, Stefan and Mallmann, Peter and Kurzeder, Christian and Hagen, Volker and van Oorschot, Birgitt and Hoecht, Stefan and Feyer, Petra and Egerer, Gerlinde and Friedrich, Michael and Cremer, Wolfgang and Prott, Franz-Josef and Horn, Lars-Christian and Prompeler, Heinrich and Langrehr, Jan and Leinung, Steffen and Beckmann, Matthias W. and Kimmig, Rainer and Letsch, Anne and Reinhardt, Michael and Alt-Epping, Bernd and Kiesel, Ludwig and Menke, Jan and Gebhardt, Marion and Steinke-Lange, Verena and Rahner, Nils and Lichtenegger, Werner and Zeimet, Alain and Hanf, Volker and Weis, Joachim and Mueller, Michael and Henscher, Ulla and Schmutzler, Rita K. and Meindl, Alfons and Hilpert, Felix and Panke, Joan Elisabeth and Strnad, Vratislav and Niehues, Christiane and Dauelsberg, Timm and Niehoff, Peter and Mayr, Doris and Grab, Dieter and Kreissl, Michael and Witteler, Ralf and Schorsch, Annemarie and Mustea, Alexander and Petru, Edgar and Huebner, Jutta and Rose, Anne Derke and Wight, Edward and Tholen, Reina and Bauerschmitz, Gerd J. and Fleisch, Markus and Juhasz-Boess, Ingolf and Lax, Sigurd and Runnebaum, Ingo and Tempfer, Clemens and Nothacker, Monika J. and Bloedt, Susanne and Follmann, Markus and Langer, Thomas and Raatz, Heike and Wesselmann, Simone and Erdogan, Saskia (2018) Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Number 032/034-OL, April 2018) - Part 2 with Recommendations on the Therapy and Follow-up of Endometrial Cancer, Palliative Care, Psycho-oncological/Psychosocial Care/Rehabilitation/Patient Information and Healthcare Facilities. GEBURTSHILFE UND FRAUENHEILKUNDE, 78 (11). pp. 1089-1109. ISSN 0016-5751, 1438-8804
Full text not available from this repository. (Request a copy)Abstract
The first German interdisciplinary S3-guideline on the diagnosis, therapy and follow-up of patients with endometrial cancer was published in April 2018. Funded by German Cancer Aid as part of an Oncology Guidelines Program, the lead coordinators of the guideline were the German Society of Gynecology and Obstetrics (DGGG) and the Gynecological Oncology Working Group (AGO) of the German Cancer Society (DKG). Purpose Using evidence-based, risk-adapted therapy to treat low-risk women with endometrial cancer avoids unnecessarily radical surgery and non-useful adjuvant radiotherapy and/or chemotherapy. This can significantly reduce therapy-induced morbidity and improve the patient's quality of life as well as avoiding unnecessary costs. For women with endometrial cancer and a high risk of recurrence, the guideline defines the optimal extent of surgical radicality together with the appropriate chemotherapy and/or adjuvant radiotherapy if required. An evidence-based optimal use of different therapeutic modalities should improve the survival rates and quality of life of these patients. This S3-guideline on endometrial cancer is intended as a basis for certified gynecological cancer centers. The aim is that the quality indicators established in this guideline will be incorporated in the certification processes of these centers. Methods The guideline was compiled in accordance with the requirements for S3-level guidelines. This includes, in the first instance, the adaptation of source guidelines selected using the DELBI instrument for appraising guidelines. Other consulted sources included reviews of evidence, which were compiled from literature selected during systematic searches of literature databases using the PICO scheme. In addition, an external biostatistics institute was commissioned to carry out a systematic search and assessment of the literature for one part of the guideline. Identified materials were used by the interdisciplinary working groups to develop suggestions for Recommendations and Statements, which were then subsequently modified during structured consensus conferences and/or additionally amended online using the DELPHI method, with consent between members achieved online. The guideline report is freely available online. Recommendations Part 2 of this short version of the guideline presents recommendations for the therapy of endometrial cancer including precancers and early endometrial cancer as well as recommendations on palliative medicine, psychooncology, rehabilitation, patient information and healthcare facilities to treat endometrial cancer. The management of precancers of early endometrial precancerous conditions including fertility-preserving strategies is presented. The concept used for surgical primary therapy of endometrial cancer is described. Radiotherapy and adjuvant medical therapy to treat endometrial cancer and uterine carcinosarcomas are described. Recommendations are given for the follow-up care of endometrial cancer, recurrence and metastasis. Palliative medicine, psycho-oncology including psychosocial care, and patient information and rehabilitation are presented. Finally, the care algorithm and quality assurance steps for the diagnosis, therapy and follow-up of patients with endometrial cancer are outlined.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; PHASE-III TRIAL; STAGE-I; PELVIC RADIOTHERAPY; RADIATION-THERAPY; PHYSICAL-ACTIVITY; UTERINE CARCINOSARCOMA; CYTOREDUCTIVE SURGERY; ADJUVANT RADIOTHERAPY; endometrial cancer; guideline; precancers; therapy; follow up |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Oct 2019 09:04 |
| Last Modified: | 10 Oct 2019 09:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13593 |
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