Megele, Richard and Riemenschneider, Markus J. and Dodoo-Schittko, Frank and Feyrer, Matthias and Kleindienst, Andrea (2018) Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series. ONCOLOGY LETTERS, 16 (5). pp. 5813-5822. ISSN 1792-1074, 1792-1082
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Despite progress in surgery and radiochemotherapy, the prognosis of glioblastoma (GB) remains poor. GB cells exhibit a preference for hypoxia to maintain their tumor-forming capacity. Treatment strategies utilizing oxygen (O-2) or ozone (O-3) and generating reactive oxygen species induce cell growth inhibition and apoptosis. The anti-tumorigenic properties of O-2-O-3 are accompanied by a key role in regulating immunogenicity. The present study reported a case series of an intra-tumoral O-2-O-3 application in recurrent GB. Following surgery in combination with standard radiochemotherapy, O-2-O-3 (5 ml at 40 mu g/ml) was applied every four weeks into the tumor vicinity. The patients received a median of 27 (range, 3-44) O-2-O-3 applications. In addition, a systematic literature search was performed in order to evaluate the role of O-3 in the treatment of malignancies. The median overall survival rate was 40 (range, 16-53) months. The median survival rate following the first recurrence or the initiation of the O-2-O-3 treatment, respectively, was 34 (range, 12-53) months. In one patient, a local infection and in another, hemorrhage occurred, necessitating in both the temporary removal of the reservoir. The data from the present study support the potential benefit of an intra-tumoral O-2-O-3 application in recurrent GB. The scientific literature revealed by the bibliographic search suggests that O-3 may be considered a viable adjuvant therapy in oncological patients. The present study may serve as a starting point for further observational and clinical studies elucidating the cellular and systemic effects of O-2 and/or O-3 and demonstrating their efficacy and safety in larger patient samples.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLIOMA-CELLS; MEDICAL OZONE; HYPOXIA; THERAPY; EXPOSURE; SURVIVAL; CANCER; MICE; OSTEONECROSIS; RADIOTHERAPY; glioblastoma; ozone; oxygen; intra-tumoral treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Neuropathologie Medicine > Institut für Epidemiologie und Präventivmedizin > Medical Sociology |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Oct 2019 09:58 |
| Last Modified: | 10 Oct 2019 09:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13635 |
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