Schueler-Toprak, Susanne and Weber, Florian and Skrzypczak, Maciej and Ortmann, Olaf and Treeck, Oliver (2018) Estrogen receptor beta is associated with expression of cancer associated genes and survival in ovarian cancer. BMC CANCER, 18: UNSP 981. ISSN 1471-2407,
Full text not available from this repository. (Request a copy)Abstract
BackgroundIn ovarian cancer, the role of estrogen receptors (ERs), particularly of ER, being suggested as tumor suppressor in breast and prostate cancer, remains unclear. We examined the expression of nuclear and cytoplasmic ER in ovarian cancer and correlated it with expression of ovarian cancer markers CA125, CEA and CA72-4, steroid hormone receptors ER and PR, cancer-associated genes EGFR, p53, HER2 and proliferation marker Ki-67. Additionally we examined to what extent expression of ER and the other proteins affects survival of ovarian cancer patients.MethodsWe established a tissue microarray from 171 ovarian cancer patients and performed immunohistochemical analyses of the mentioned proteins.ResultsNuclear ER was detected in 47.31% of the ovarian cancer tissues and cytoplasmic expression of this receptor was observed in 23.08%. Nuclear expression of ER was significantly decreased in the G3 subgroup compared to better differentiated cancers (p<0.01) and correlated with ovarian cancer markers CEA (95% CI 0.1598-0.4465; p<0.0001) and CA72-4 (95% CI 0.05953-0.3616; p<0.01). Cytoplasmic ER expression correlated with EGFR levels (95% CI 0.1059-0.4049; p<0.001). ER expression was associated with expression of CA125 and PR. Overall survival of patients with tumors expressing cytoplasmic ER was significant longer compared to those with ER-negative ovarian cancer (chi-square statistic of the log-rank, p<0.05). Progression-free survival was dependent on expression of PR (chi-square statistic of the log-rank, p<0.05) and Ki-67 (p=0.05).ConclusionsOur data suggest an important, but distinct role of nuclear and cytoplasmic ER expression in ovarian cancer and encourage further studies on its role in this cancer entity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGESTERONE-RECEPTOR; PROGNOSTIC VALUE; DOWN-REGULATION; ER-BETA; CARCINOMA; GROWTH; CELLS; TISSUE; TAMOXIFEN; APOPTOSIS; Estrogen receptor; Ovarian cancer; Overall survival; Progression-free survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Dec 2019 08:33 |
| Last Modified: | 05 Dec 2019 08:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13686 |
Actions (login required)
 |
View Item |
