Tahedl, Marlene and Levine, Seth M. and Greenlee, Mark W. and Weissert, Robert and Schwarzbach, Jens V. (2018) Functional Connectivity in Multiple Sclerosis: Recent Findings and Future Directions. FRONTIERS IN NEUROLOGY, 9: 828. ISSN 1664-2295
Full text not available from this repository. (Request a copy)Abstract
Multiple sclerosis is a debilitating disorder resulting from scattered lesions in the central nervous system. Because of the high variability of the lesion patterns between patients, it is difficult to relate existing biomarkers to symptoms and their progression. The scattered nature of lesions in multiple sclerosis offers itself to be studied through the lens of network analyses. Recent research into multiple sclerosis has taken such a network approach by making use of functional connectivity. In this review, we briefly introduce measures of functional connectivity and how to compute them. We then identify several common observations resulting from this approach: (a) high likelihood of altered connectivity in deep-gray matter regions, (b) decrease of brain modularity, (c) hemispheric asymmetries in connectivity alterations, and (d) correspondence of behavioral symptoms with task-related and task-unrelated networks. We propose incorporating such connectivity analyses into longitudinal studies in order to improve our understanding of the underlying mechanisms affected by multiple sclerosis, which can consequently offer a promising route to individualizing imaging-related biomarkers for multiple sclerosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESTING-STATE CONNECTIVITY; CLINICALLY ISOLATED SYNDROME; RELAPSING-REMITTING MS; COGNITIVE REHABILITATION; BRAIN CONNECTIVITY; NETWORK CENTRALITY; WORKING-MEMORY; MOTOR CORTEX; FMRI DATA; DISABILITY; fMRI; functional connectivity; multiple sclerosis; resting state; neuroimaging biomarker |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Petra Gürster |
| Date Deposited: | 17 Jul 2020 06:46 |
| Last Modified: | 17 Jul 2020 06:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13697 |
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