De Schepper, Sebastiaan and Verheijden, Simon and Aguilera-Lizarraga, Javier and Viola, Maria Francesca and Boesmans, Werend and Stakenborg, Nathalie and Voytyuk, Iryna and Smidt, Inga and Boeckx, Bram and de Casterle, Isabelle Dierckx and Baekelandt, Veerle and Dominguez, Erika Gonzalez and Mack, Matthias and Depoortere, Inge and De Strooper, Bart and Sprangers, Ben and Himmelreich, Uwe and Soenen, Stefaan and Guilliams, Martin and Vanden Berghe, Pieter and Jones, Elizabeth and Lambrechts, Diether and Boeckxstaens, Guy (2018) Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis. CELL, 175 (2). 400-+. ISSN 0092-8674, 1097-4172
Full text not available from this repository. (Request a copy)Abstract
Macrophages are highly heterogeneous tissue-resident immune cells that perform a variety of tissue- supportive functions. The current paradigm dictates that intestinal macrophages are continuously replaced by incoming monocytes that acquire a pro-inflammatory or tissue-protective signature. Here, we identify a self-maintaining population of macrophages that arise from both embryonic precursors and adult bone marrow-derived monocytes and persists throughout adulthood. Gene expression and imaging studies of self-maintaining macrophages revealed distinct transcriptional profiles that reflect their unique localization (i.e., closely positioned to blood vessels, submucosal and myenteric plexus, Paneth cells, and Peyer's patches). Depletion of self-maintaining macrophages resulted in morphological abnormalities in the submucosal vasculature and loss of enteric neurons, leading to vascular leakage, impaired secretion, and reduced intestinal motility. These results provide critical insights in intestinal macrophage heterogeneity and demonstrate the strategic role of self-maintaining macrophages in gut homeostasis and intestinal physiology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPRESSION PROFILES; ADULT MICROGLIA; TISSUE; CELL; MONOCYTES; RESPONSES; IDENTITY; REVEALS; ORIGINS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Dec 2019 13:21 |
| Last Modified: | 05 Dec 2019 13:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13707 |
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