Heits, Nils and Brosch, Mario and Herrmann, Alexander and Behrens, Robin and Roecken, Christoph and Schrem, Harald and Kaltenborn, Alexander and Klempnauer, Juergen and Kreipe, Hans-Heinrich and Reichert, Benedikt and Lenschow, Christina and Wilms, Christian and Vogel, Thomas and Wolters, Heiner and Wardelmann, Eva and Seehofer, Daniel and Buch, Stephan and Zeissig, Sebastian and Pannach, Sven and Raschzok, Nathanael and Dietel, Manfred and von Schoenfels, Witigo and Hinz, Sebastian and Teufel, Andreas and Evert, Matthias and Franke, Andre and Becker, Thomas and Braun, Felix and Hampe, Jochen and Schafmayer, Clemens (2018) Evolutionary Distance Predicts Recurrence After Liver Transplantation in Multifocal Hepatocellular Carcinoma. TRANSPLANTATION, 102 (10). E424-E430. ISSN 0041-1337, 1534-6080
Full text not available from this repository. (Request a copy)Abstract
Background Liver transplantation (LTx) is a potentially curative treatment option for hepatocellular carcinoma (HCC) in cirrhosis. However, patients, where HCC is already a systemic disease, LTx may be individually harmful and has a negative impact on donor organ usage. Thus, there is a need for improved selection criteria beyond nodule morphology to select patients with a favorable outcome for LTx in multifocal HCC. Evolutionary distance measured from genome-wide single-nucleotide polymorphism data between tumor nodules and the cirrhotic liver may be a prognostic marker of survival after LTx for multifocal HCC. Methods In a retrospective multicenter study, clinical data and formalin-fixed paraffin-embedded specimens of the liver and 2 tumor nodules were obtained from explants of 30 patients in the discovery and 180 patients in the replication cohort. DNA was extracted from formalin-fixed paraffin-embedded specimens followed by genome wide single-nucleotide polymorphism genotyping. Results Genotype quality criteria allowed for analysis of 8 patients in the discovery and 17 patients in the replication set. DNA concentrations of a total of 25 patients fulfilled the quality criteria and were included in the analysis. Both, in the discovery (P = 0.04) and in the replication data sets (P = 0.01), evolutionary distance was associated with the risk of recurrence of HCC after transplantation (combined P = 0.0002). In a univariate analysis, evolutionary distance (P = 7.4 x 10(-6)) and microvascular invasion (P = 1.31 x 10(-5)) were significantly associated with survival in a Cox regression analysis. Conclusions Evolutionary distance allows for the determination of a high-risk group of recurrence if preoperative liver biopsy is considered.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MICROVASCULAR INVASION; TUMOR RECURRENCE; SELECTION; CRITERIA; CANCER; MANAGEMENT; IMPACT; CHEMOEMBOLIZATION; F-18-FDG-PET; METASTASIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Dec 2019 10:14 |
| Last Modified: | 09 Dec 2019 10:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13747 |
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