Seel, Catharina Julia and Kralik, Antonin and Hacker, Melanie and Frank, Annika and Koenig, Burkhard and Gulder, Tanja (2018) Atom-Economic Electron Donors for Photobiocatalytic Halogenations. CHEMCATCHEM, 10 (18). pp. 3960-3963. ISSN 1867-3880, 1867-3899
Full text not available from this repository. (Request a copy)Abstract
In vitro cofactor supply and regeneration have been a major obstacle for biocatalytic processes, in particular on a large scale. Peroxidases often suffer from inactivation by their oxidative co-factor. Combining photocatalysis and biocatalysis offers an innovative solution to this problem, but lacks atom economy due to the sacrificial electron donors needed. Herein, we show that redox-active buffers or even water alone can serve as efficient, biocompatible electron sources, when combined with photocatalysis. Mechanistic investigations revealed first insights into the possibilities and limitations of this approach and allowed adjusting the reaction conditions to the specific needs of biocatalytic transformations. Proof-of-concept for the applicability of this photobiocatalytic reaction setup was given by enzymatic halogenations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CURVULARIA-INAEQUALIS; VANADIUM CHLOROPEROXIDASE; HYDROGEN-PEROXIDE; ENANTIOSELECTIVE SULFOXIDATION; INACTIVATION; OXIDATION; BROMOPEROXIDASE; PHOTOCATALYSIS; HALOPEROXIDASE; INHIBITION; Biocatalysis; Photocatalysis; Water splitting; Sustainable Chemistry; Halogenation |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Dec 2019 14:04 |
| Last Modified: | 12 Dec 2019 14:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13840 |
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