Haimerl, Michael and Probst, Ute and Poelsterl, Stefanie and Fellner, Claudia and Nickel, Dominik and Weigand, Kilian and Brunner, Stefan M. and Zeman, Florian and Stroszczynski, Christian and Wiggermann, Philipp (2018) Evaluation of two-point Dixon water-fat separation for liver specific contrast-enhanced assessment of liver maximum capacity. SCIENTIFIC REPORTS, 8: 13863. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Gadoxetic acid-enhanced magnetic resonance imaging has become a useful tool for quantitative evaluation of liver capacity. We report on the importance of intrahepatic fat on gadoxetic acidsupported T1 mapping for estimation of liver maximum capacity, assessed by the realtime C-13-methacetin breathing test (C-13-MBT). For T1 relaxometry, we used a respective T1-weighted sequence with two-point Dixon water-fat separation and various flip angles. Both T1 maps of the inphase component without fat separation (T1_in) and T1 maps merely based on the water component (T1_W) were generated, and respective reduction rates of the T1 relaxation time (rrT1) were evaluated. A steady considerable decline in rrT1 with progressive reduction of liver function could be observed for both T1_in and T1_W (p < 0.001). When patients were subdivided into 3 different categories of C-13-MBT readouts, the groups could be significantly differentiated by their rrT1_in and rrT1_W values (p < 0.005). In a simple correlation model of C-13-MBT values with T1_inpost (r = 0.556; p < 0.001), T1_Wpost (r = 0.557; p < 0.001), rrT1_in (r = 0.711; p < 0.001) and rrT1_W (r = 0.751; p < 0.001), a loglinear correlation has been shown. Liver maximum capacity measured with C-13-MBT can be determined more precisely from gadoxetic acid-supported T1 mapping when intrahepatic fat is taken into account. Here, T1_W maps are shown to be significantly superior to T1_in maps without separation of fat.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GD-EOB-DTPA; INTENSITY-BASED INDEXES; T1 RELAXOMETRY; LIMAX TEST; MRI; SUPPRESSION; CIRRHOSIS; DISEASE; PROTON; VOLUME; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2019 08:15 |
| Last Modified: | 13 Dec 2019 08:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13860 |
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