Ji, Xiangming and Qian, Jun and Rahman, S. M. Jamshedur and Siska, Peter J. and Zou, Yong and Harris, Bradford K. and Hoeksema, Megan D. and Trenary, Irina A. and Heidi, Chen and Eisenberg, Rosana and Rathmell, Jeffrey C. and Young, Jamey D. and Massion, Pierre P. (2018) xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. ONCOGENE, 37 (36). pp. 5007-5019. ISSN 0950-9232, 1476-5594
Full text not available from this repository. (Request a copy)Abstract
Many tumors increase uptake and dependence on glucose, cystine or glutamine. These basic observations on cancer cell metabolism have opened multiple new diagnostic and therapeutic avenues in cancer research. Recent studies demonstrated that smoking could induce the expression of xCT (SLC7A11) in oral cancer cells, suggesting that overexpression of xCT may support lung tumor progression. We hypothesized that overexpression of xCT occurs in lung cancer cells to satisfy the metabolic requirements for growth and survival. Our results demonstrated that 1) xCT was highly expressed at the cytoplasmic membrane in non-small cell lung cancer (NSCLC), 2) the expression of xCT was correlated with advanced stage and predicted a worse 5-year survival, 3) targeting xCT transport activity in xCT overexpressing NSCLC cells with sulfasalazine decreased cell proliferation and invasion in vitro and in vivo and 4) increased dependence on glutamine was observed in xCT overexpressed normal airway epithelial cells. These results suggested that xCT regulate metabolic requirements during lung cancer progression and be a potential therapeutic target in NSCLC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLUTAMATE TRANSPORTER SLC7A11; CYSTINE/GLUTAMATE ANTIPORTER; GLUTAMINASE EXPRESSION; OXIDATIVE-STRESS; CIGARETTE-SMOKE; GROWTH; APOPTOSIS; INHIBITION; OVEREXPRESSION; SENSITIVITY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2019 09:17 |
| Last Modified: | 13 Dec 2019 09:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13876 |
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