Seliger, Corinna and Hau, Peter (2018) Drug Repurposing of Metabolic Agents in Malignant Glioma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19 (9): 2768. ISSN 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Gliomas are highly invasive brain tumors with short patient survival. One major pathogenic factor is aberrant tumor metabolism, which may be targeted with different specific and unspecific agents. Drug repurposing is of increasing interest in glioma research. Drugs interfering with the patient's metabolism may also influence glioma metabolism. In this review, we outline definitions and methods for drug repurposing. Furthermore, we give insights into important candidates for a metabolic drug repurposing, namely metformin, statins, non-steroidal anti-inflammatory drugs, disulfiram and lonidamine. Advantages and pitfalls of drug repurposing will finally be discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEWLY-DIAGNOSED GLIOBLASTOMA; RANDOMIZED PHASE-II; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CELL LUNG-CANCER; DOUBLE-BLIND; STEM-CELLS; STATIN USE; METRONOMIC CHEMOTHERAPY; ALDEHYDE DEHYDROGENASE; INHIBITOR RITONAVIR; glioma; glioblastoma; drug repurposing; metformin; statin; NSAR; disulfiram; lonidamine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Jul 2020 11:52 |
| Last Modified: | 09 Jul 2020 11:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13910 |
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