Schmid, Christian and Delacher, Michael and Huehn, Jochen and Feuerer, Markus (2018) Epigenetic mechanisms regulating T-cell responses. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 142 (3). pp. 728-743. ISSN 0091-6749, 1097-6825
Full text not available from this repository. (Request a copy)Abstract
During the last decade, advances in sequencing technologies allowed production of a wealth of information on epigenetic modifications in T cells. Epigenome maps, in combination with mechanistic studies, have demonstrated that T cells undergo extensive epigenome remodeling in response to signals, which has a strong effect on phenotypic stability and function of lymphocytes. In this review we focus on DNA methylation, histone modifications, and chromatin structure as important epigenetic mechanisms involved in controlling T-cell responses. In particular, we discuss epigenetic processes in light of the development, activation, and differentiation of CD4(+) T helper (T-H), regulatory T, and CD8(+) T cells. As central aspects of the adaptive immune system, we review mechanisms that ensure molecular memory, stability, plasticity, and exhaustion of T cells. We further discuss the effect of the tissue environment on imprinting T-cell epigenomes with potential implications for immunotherapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NOVO DNA METHYLATION; CHROMATIN ACCESSIBILITY; TRANSCRIPTION FACTORS; FOXP3 EXPRESSION; GENE-EXPRESSION; CIS-ELEMENT; ENHANCER; DIFFERENTIATION; MEMORY; CD4; Epigenetics; gene regulation; enhancer; promoter; chromatin accessibility; histone modifications; DNA methylation; transcription factor binding; T-cell development; T-cell function; T-cell exhaustion; regulatory T cells; tissue specificity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jan 2020 08:13 |
| Last Modified: | 09 Jan 2020 08:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13968 |
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