Banas, Miriam and Neumann, Sindy and Eiglsperger, Johannes and Schiffer, Eric and Putz, Franz Josef and Reichelt-Wurm, Simone and Kraemer, Bernhard Karl and Pagel, Philipp and Banas, Bernhard (2018) Identification of a urine metabolite constellation characteristic for kidney allograft rejection. METABOLOMICS, 14 (9): 116. ISSN 1573-3882, 1573-3890
Full text not available from this repository. (Request a copy)Abstract
Allograft rejection is still an important complication after kidney transplantation. Currently, monitoring of these patients mostly relies on the measurement of serum creatinine and clinical evaluation. The gold standard for diagnosing allograft rejection, i.e. performing a renal biopsy is invasive and expensive. So far no adequate biomarkers are available for routine use. We aimed to develop a urine metabolite constellation that is characteristic for acute renal allograft rejection. NMR-Spectroscopy was applied to a training cohort of transplant recipients with and without acute rejection. We obtained a metabolite constellation of four metabolites that shows promising performance to detect renal allograft rejection in the cohorts used (AUC of 0.72 and 0.74, respectively). A metabolite constellation was defined with the potential for further development of an in-vitro diagnostic test that can support physicians in their clinical assessment of a kidney transplant patient.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NUCLEAR-MAGNETIC-RESONANCE; RENAL-ALLOGRAFT; SPECTROSCOPY; BIOPSIES; SAFETY; PLASMA; Metabolomics; NMR-spectroscopy; Kidney rejection; Diagnostic model |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jan 2020 12:58 |
| Last Modified: | 09 Jan 2020 12:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13979 |
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