Schecklmann, Martin and Weidler, Carmen and Eichhammer, Peter and Hajak, Goeran and Langguth, Berthold (2018) Increased short-interval intracortical inhibition in un-medicated patients with schizophrenia. BRAIN STIMULATION, 11 (5). pp. 1080-1082. ISSN 1935-861X, 1876-4754
Full text not available from this repository. (Request a copy)Abstract
Background: Schizophrenia is associated with changes in inhibitory and facilitatory brain networks which can be assessed by motor cortex excitability. Objective: Here, we investigate differences between large cross-sectional samples of un-medicated and medicated patients with schizophrenia and healthy controls in single- and double-pulse transcranial magnetic stimulation parameters. Methods: We measured right abductor digiti minimi muscle activity in 71 un-medicated, 43 medicated patients and 131 healthy controls. To exclude sample bias analyses were repeated with groups comparable for age and gender (un-medicated: n = 43; medicated: n = 38; controls: n = 49). Results: Un-medicated patients showed increased short-interval intracortical inhibition (SICI) in contrast to medicated patients and healthy controls. No group differences were found for resting and active motor threshold, cortical silent period and intracortical facilitation. Conclusion: Increases in SICI are in contrast to literature and highlight the necessity for large-scaled multi-centric studies with high methodological standards. (C) 2018 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; CORTICAL SILENT PERIOD; PSYCHIATRIC-DISORDERS; EXCITABILITY; Transcranial magnetic stimulation; Double pulse TMS; Motor cortex; Cortical excitability; Psychosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jan 2020 15:10 |
| Last Modified: | 09 Jan 2020 15:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/13998 |
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