Cazzaniga, Simone and Ballmer-Weber, Barbara K. and Grani, Nora and Spring, Philippe and Bircher, Andreas and Anliker, Mark and Sonntag, Anne-Katharina and Piletta, Pierre and Huber, Caroline and Diepgen, Thomas L. and Apfelbacher, Christian and Naldi, Luigi and Borradori, Luca and Simon, Dagmar (2018) Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement. CONTACT DERMATITIS, 79 (3). pp. 136-148. ISSN 0105-1873, 1600-0536
Full text not available from this repository. (Request a copy)Abstract
BackgroundHand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce. ObjectiveTo evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2years. MethodsData of the prospective patient cohort (N=199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses. ResultsBoth severity of HE and QoL significantly improved over the period of 2 years (P<.001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified. ConclusionsAnalysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOLLOW-UP; RISK-FACTORS; GENERAL-POPULATION; PREVALENCE; CONSEQUENCES; DERMATITIS; SEVERITY; CORTICOSTEROIDS; ALITRETINOIN; PROGNOSIS; CARPE; chronic hand eczema; clinical improvement; epidemiology; follow-up; quality of life; semantic map analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Medical Sociology |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jan 2020 15:22 |
| Last Modified: | 09 Jan 2020 15:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14001 |
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