Haimerl, Michael and Fuhrmann, Irene and Poelsterl, Stefanie and Fellner, Claudia and Nickel, Marcel D. and Weigand, Kilian and Dahlke, Marc H. and Verloh, Niklas and Stroszczynski, Christian and Wiggermann, Philipp (2018) Gd-EOB-DTPA-enhanced T1 relaxometry for assessment of liver function determined by real-time C-13-methacetin breath test. EUROPEAN RADIOLOGY, 28 (9). pp. 3591-3600. ISSN 0938-7994, 1432-1084
Full text not available from this repository. (Request a copy)Abstract
To determine whether liver function as determined by intravenous administration of C-13-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) relaxometry. Sixty-six patients underwent a C-13-methacetin breath test (C-13-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration. The reduction rate of T1 relaxation time (rrT1) and T1 relaxation velocity index (a dagger R1) between pre- and post-contrast images was evaluated. C-13-MBT values were correlated with T1(post), a dagger R1 and rrT1, providing an MRI-based estimated C-13-MBT value. The interobserver reliability was assessed by determining the intraclass correlation coefficient (ICC). Stratified by three different categories of C-13-MBT readouts, there was a constant increase of T1 post with increasing progression of diminished liver function (p <= 0.030) and a constant significant decrease of a dagger R1 (p <= 0.025) and rrT1 (p < 0.018) with progression of liver damage as assessed by C-13-methacetin breath analysis. ICC for all T1 relaxation values and indices was excellent (> 0.88). A simple regression model showed a log-linear correlation of C-13-MBT values with T1(post) (r = 0.57; p < 0.001), a dagger R1 (r = 0.59; p < 0.001) and rrT1 (r = 0.70; p < 0.001). Liver function as determined using real-time C-13-methacetin breath analysis can be estimated quantitatively from Gd-EOB-DTPA-enhanced MR relaxometry. aEuro cent Gd-EOB-DTPA-enhanced T1 relaxometry quantifies liver function aEuro cent Gd-EOB-DTPA-enhanced MR relaxometry may provide parameters for assessing liver function before surgery aEuro cent Gd-EOB-DTPA-enhanced MR relaxometry may be useful for monitoring liver disease progression aEuro cent Gd-EOB-DTPA-enhanced MR relaxometry has the potential to become a novel liver function index.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATIC-UPTAKE; RELAXATION-TIME; CONTRAST AGENT; MR RELAXOMETRY; LIMAX TEST; CIRRHOSIS; TRANSPLANTATION; HEPATECTOMY; EXPRESSION; FAILURE; Contrast media; Liver diseases; Liver function tests; Breath test; Magnetic resonance imaging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Jan 2020 07:30 |
| Last Modified: | 10 Jan 2020 07:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14007 |
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