Ndumbi, Patricia and Freidl, Gudrun S. and Williams, Christopher J. and Mardh, Otilia and Varela, Carmen and Avellon, Ana and Friesema, Ingrid and Vennema, Harry and Beebeejaun, Kazim and Ngui, Siew Lin and Edelstein, Michael and Smith-Palmer, Alison and Murphy, Niamh and Dean, Jonathan and Faber, Mirko and Wenzel, Juergen and Kontio, Mia and Muller, Luise and Midgley, Sofie Elisabeth and Sundqvist, Lena and Ederth, Josefine Lundberg and Roque-Afonso, Anne-Marie and Couturier, Elisabeth and Klamer, Sofieke and Rebolledo, Javiera and Suin, Vanessa and Aberle, Stephan W. and Schmid, Daniela and De Sousa, Rita and Augusto, Goncalo Figueiredo and Alfonsi, Valeria and Del Manso, Martina and Ciccaglione, Anna Rita and Mellou, Kassiani and Hadjichristodoulou, Christos and Donachie, Alastair and Borg, Maria-Louise and Socan, Maja and Poljak, Mario and Severi, Ettore (2018) Hepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017. EUROSURVEILLANCE, 23 (33): 1700641. pp. 2-13. ISSN 1560-7917,
Full text not available from this repository. (Request a copy)Abstract
Between 1 June 2016 and 31 May 2017, 17 European Union (EU) and European Economic Area countries reported 4,096 cases associated with a multi-country hepatitis A (HA) outbreak. Molecular analysis identified three co-circulating hepatitis A virus (HAV) strains of genotype IA: VRD_521_ 2016, V16-25801 and RIVM-HAV16-090. We categorised cases as confirmed, probable or possible, according to the EU outbreak case definitions. Confirmed cases were infected with one of the three outbreak strains. We investigated case characteristics and strain-specific risk factors for transmission. A total of 1,400 (34%) cases were confirmed; VRD_521_ 2016 and RIVM-HAV16-090 accounted for 92% of these. Among confirmed cases with available epidemiological data, 92% (361/393) were unvaccinated, 43% (83/195) travelled to Spain during the incubation period and 84% (565/676) identified as men who have sex with men (MSM). Results depict an HA outbreak of multiple HAV strains, within a cross-European population, that was particularly driven by transmission between non-immune MSM engaging in high-risk sexual behaviour. The most effective preventive measure to curb this outbreak is HAV vaccination of MSM, supplemented by primary prevention campaigns that target the MSM population and promote protective sexual behaviour.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VIRUS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Jan 2020 10:08 |
| Last Modified: | 10 Jan 2020 10:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14045 |
Actions (login required)
 |
View Item |
