Mack, Matthias (2018) Inflammation and fibrosis. MATRIX BIOLOGY, 68-69. pp. 106-121. ISSN 0945-053X, 1569-1802
Full text not available from this repository. (Request a copy)Abstract
Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue damage not only induces inflammation in general, it also determines the type and polarization of inflammation by recruiting and activating a variety of different cells types of the innate and adaptive immune system. This review focuses on the pathways leading from tissue damage to inflammation, from inflammation to fibrosis and from fibrosis to function. It covers the pro-and antifibrotic properties of immunological mediators released from T cells, monocytes/macrophages, innate lymphoid cells, basophils and eosinophils and takes into account that extracellular matrix proteins are not only produced by mesenchymal fibroblasts but also by other cell types, especially infiltrating hematopoietic cells. The special requirements for activation and recruitment of these so called fibrocytes are described in detail. (C) 2017 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-BETA; INNATE LYMPHOID-CELLS; INDUCED LUNG FIBROSIS; CD4(+) T-CELLS; ALTERNATIVELY ACTIVATED MACROPHAGES; PERICYTE-MYOFIBROBLAST TRANSITION; PERIPHERAL-BLOOD FIBROCYTES; INDUCED PULMONARY-FIBROSIS; LIMIT DISEASE-ACTIVITY; Tissue damage; Inflammation; Fibrosis; Fibrocytes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 02 Jul 2020 13:37 |
| Last Modified: | 02 Jul 2020 13:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14105 |
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