Waage, Johannes and Standl, Marie and Curtin, John A. and Jessen, Leon E. and Thorsen, Jonathan and Tian, Chao and Schoettler, Nathan and Flores, Carlos and Abdellaoui, Abdel and Ahluwalia, Tarunveer S. and Alves, Alexessander C. and Amaral, Andre F. S. and Anto, Josep M. and Arnold, Andreas and Barreto-Luis, Amalia and Baurecht, Hansjoerg and van Beijsterveldt, Catharina E. M. and Bleecker, Eugene R. and Bonas-Guarch, Silvia and Boomsman, Dorret I. and Brix, Susanne and Bunyavanich, Supinda and Burchard, Esteban G. and Chen, Zhanghua and Curjuric, Ivan and Custovic, Adnan and den Dekker, Herman T. and Dharmage, Shyamali C. and Dmitrieva, Julia and Duijts, Liesbeth and Ege, Markus J. and Gauderman, W. James and Georges, Michel and Gieger, Christian and Gilliland, Frank and Granell, Raquel and Gui, Hongsheng and Hansen, Torben and Heinrich, Joachim and Henderson, John and Hernandez-Pacheco, Natalia and Holt, Patrick and Imboden, Medea and Jaddoe, Vincent W. V. and Jarvelin, Marjo-Riitta and Jarvis, Deborah L. and Jensen, Kamilla K. and Jonsdottir, Ingileif and Kabesch, Michael and Kaprio, Jaakko and Kumar, Ashish and Lee, Young-Ae and Levin, Albert M. and Li, Xingnan and Lorenzo-Diaz, Fabian and Melen, Erik and Mercader, Josep M. and Meyers, Deborah A. and Myers, Rachel and Nicolae, Dan L. and Nohr, Ellen A. and Palviainen, Teemu and Paternoster, Lavinia and Pennell, Craig E. and Pershagen, Goran and Pino-Yanes, Maria and Probst-Hensch, Nicole M. and Ruschendorf, Franz and Simpson, Angela and Stefansson, Kari and Sunyer, Jordi and Sveinbjornsson, Gardar and Thiering, Elisabeth and Thompson, Philip J. and Torrent, Maties and Torrents, David and Tung, Joyce Y. and Wang, Carol A. and Weidinger, Stephan and Weiss, Scott and Willemsen, Gonneke and Williams, L. Keoki and Ober, Carole and Hinds, David A. and Ferreira, Manuel A. and Bisgaard, Hans and Strachan, David P. and Bonnelykke, Klaus (2018) Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. NATURE GENETICS, 50 (8). 1072-+. ISSN 1061-4036, 1546-1718
Full text not available from this repository. (Request a copy)Abstract
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries(1,2). To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HAY-FEVER; CELL DEVELOPMENT; DENDRITIC CELLS; EXPRESSION; VARIANTS; ASTHMA; RECEPTOR; HERITABILITY; METAANALYSIS; DISEASES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Mar 2020 13:01 |
| Last Modified: | 05 Mar 2020 13:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14108 |
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