Mayr, Roman and Fritsche, Hans-Martin and Zeman, Florian and Reiffen, Marieke and Siebertz, Leopold and Niessen, Christoph and Pycha, Armin and van Rhijn, Bas W. G. and Burger, Maximilian and Gierth, Michael (2018) Sarcopenia predicts 90-day mortality and postoperative complications after radical cystectomy for bladder cancer. WORLD JOURNAL OF UROLOGY, 36 (8). pp. 1201-1207. ISSN 0724-4983, 1433-8726
Full text not available from this repository. (Request a copy)Abstract
A single-center study was conducted to investigate the impact of sarcopenia as a predictor for 90-day mortality (90 dM) and complications within 90 days after radical cystectomy for bladder cancer. In total, 327 patients with preoperative available digital computed tomography (CT) scans of the abdomen and pelvis were identified. The lumbar skeletal muscle index was measured using preoperative abdominal CT to assess sarcopenia. Complications were recorded and graded according to Clavien-Dindo (CD). Predictors of 90 dM and complications within 90 days were analyzed by uni- and multivariable logistic regression. Of the 327 patients, 262 (80%) were male and 108 (33%) patients were classified as sarcopenic. Within 90 days, 28 (7.8%) patients died, of whom 15 patients were sarcopenic and 13 were not. In multivariable logistic regression analysis, sarcopenia (OR 2.59; 95% CI 1.13-5.95; p = 0.025), ASA 3-4 (OR 2.53; 95% CI 1.10-5.82; p = 0.029) and cM + (OR 7.43; 95% CI 2.34-23.64; p = 0.001) were independent predictors of 90-day mortality. Sarcopenic patients experienced significantly more complications, i.e., CD 4a-5 (p = 0.003), compared to non-sarcopenic patients. In multivariable logistic regression analysis, sarcopenia was independently associated with CD 3b complications corrected for age, BMI, ASA-Score and type of urinary diversion. We reported that sarcopenia proved an independent predictor for 90 dM and complications in patients undergoing RC for bladder cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ALL-CAUSE MORTALITY; PERIOPERATIVE MORTALITY; COMORBIDITY INDEXES; PROGNOSTIC-FACTOR; AGE; CLASSIFICATION; DEPLETION; OUTCOMES; COHORT; Frailty; Skeletal muscle mass; Bladder cancer; Prognosis; Urinary bladder neoplasm |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Feb 2020 09:48 |
| Last Modified: | 12 Feb 2020 09:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14115 |
Actions (login required)
 |
View Item |
