Singer, Katrin and Cheng, Wan-Chen and Kreutz, Marina and Ho, Ping-Chih and Siska, Peter J. (2018) Immunometabolism in cancer at a glance. DISEASE MODELS & MECHANISMS, 11 (8): UNSP dmm03. ISSN 1754-8403, 1754-8411
Full text not available from this repository. (Request a copy)Abstract
The scientific knowledge about tumor metabolism has grown at a fascinating rate in recent decades. We now know that tumors are highly active both in their metabolism of available nutrients and in the secretion of metabolic by-products. However, cancer cells can modulate metabolic pathways and thus adapt to specific nutrients. Unlike tumor cells, immune cells are not subject to a 'micro-evolution' that would allow them to adapt to progressing tumors that continuously develop new mechanisms of immune escape. Consequently, immune cells are often irreversibly affected and may allow or even support cancer progression. The mechanisms of how tumors change immune cell function are not sufficiently explored. It is, however, clear that commonly shared features of tumor metabolism, such as local nutrient depletion or production of metabolic ` waste' can broadly affect immune cells and contribute to immune evasion. Moreover, immune cells utilize different metabolic programs based on their subtype and function, and these immunometabolic pathways can be modified in the tumor microenvironment. In this review and accompanying poster, we identify and describe the common mechanisms by which tumors metabolically affect the tumorinfiltrating cells of native and adaptive immunity, and discuss how these mechanisms may lead to novel therapeutic opportunities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | T-CELL-ACTIVATION; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; TUMORAL IMMUNE RESISTANCE; METABOLIC CHECKPOINT; GENE-EXPRESSION; GLUCOSE DEPRIVATION; LACTIC-ACID; ADENOSINE; RECEPTOR; INHIBITION; Cancer; Metabolism; Metabolites; Nutrients; T cells; Tumor immunology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Feb 2020 09:48 |
| Last Modified: | 13 Feb 2020 09:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14128 |
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