Wirth, Anna M. and Khomenko, Andrei and Baldaranov, Dobri and Kobor, Ines and Hsam, Ohnmar and Grimm, Thomas and Johannesen, Siw and Bruun, Pm-Henrik and Schulte-Mattler, Wilhelm and Greenlee, Mark W. and Bogdahn, Ulrich (2018) Combinatory Biomarker Use of Cortical Thickness, MUNIX, and ALSFRS-R at Baseline and in Longitudinal Courses of Individual Patients With Amyotrophic Lateral Sclerosis. FRONTIERS IN NEUROLOGY, 9: 614. ISSN 1664-2295,
Full text not available from this repository. (Request a copy)Abstract
Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative process affecting upper and lower motor neurons as well as non-motor systems. In this study, precentral and postcentral cortical thinning detected by structural magnetic resonance imaging (MRI) were combined with clinical (ALS-specific functional rating scale revised, ALSFRS-R) and neurophysiological (motor unit number index, MUNIX) biomarkers in both cross-sectional and longitudinal analyses. Methods: The unicenter sample included 20 limb-onset classical ALS patients compared to 30 age-related healthy controls. ALS patients were treated with standard Riluzole and additional long-term G-CSF (Filgrastim) on a named patient basis after written informed consent. Combinatory biomarker use included cortical thickness of atlas-based dorsal and ventral subdivisions of the precentral and postcentral cortex, ALSFRS-R, and MUNIX for the musculus abductor digiti minimi (ADM) bilaterally Individual cross-sectional analysis investigated individual cortical thinning in ALS patients compared to age-related healthy controls in the context of state of disease at initial MRI scan. Beyond correlation analysis of biomarkers at cross-sectional group level (n = 20), longitudinal monitoring in a subset of slow progressive ALS patients (n = 4) explored within-subject temporal dynamics of repeatedly assessed biomarkers in time courses over at least 18 months. Results: Cross-sectional analysis demonstrated individually variable states of cortical thinning, which was most pronounced in the ventral section of the precentral cortex. Correlations of ALSFRS-R with cortical thickness and MUNIX were detected. Individual longitudinal biomarker monitoring in four slow progressive ALS patients revealed evident differences in individual disease courses and temporal dynamics of the biomarkers. Conclusion: A combinatory use of structural MRI, neurophysiological and clinical biomarkers allows for an appropriate and detailed assessment of clinical state and course of disease of ALS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN CEREBRAL-CORTEX; VOXEL-BASED MORPHOMETRY; NUMBER INDEX MUNIX; MOTOR-NEURON LOSS; WHOLE-BRAIN; MRI; INVOLVEMENT; DISEASE; MUSCLES; ATROPHY; amyotrophic lateral sclerosis; magnetic resonance imaging; cortical thickness; MUNIX; ALSFRS-R |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Feb 2020 10:06 |
| Last Modified: | 12 Feb 2020 10:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14203 |
Actions (login required)
 |
View Item |
