Oberacker, Tina and Bajorat, Joerg and Ziola, Sabine and Schroeder, Anne and Roeth, Daniel and Kastl, Lena and Edgar, Bruce A. and Wagner, Wolfgang and Guelow, Karsten and Krammer, Peter H. (2018) Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging. FEBS LETTERS, 592 (13). pp. 2297-2307. ISSN 1873-3468,
Full text not available from this repository. (Request a copy)Abstract
The "free radical theory of aging" suggests that reactive oxygen species (ROS) are responsible for age-related loss of cellular functions and, therefore, represent the main cause of aging. Redox regulation by thioredoxin-1 (TRX) plays a crucial role in responses to oxidative stress. We show that thioredoxin-interacting protein (TXNIP), a negative regulator of TRX, plays a major role in maintaining the redox status and, thereby, influences aging processes. This role of TXNIP is conserved from flies to humans. Age-dependent upregulation of TXNIP results in decreased stress resistance to oxidative challenge in primary human cells and in Drosophila. Experimental overexpression of TXNIP in Hies shortens lifespan due to elevated oxidative DNA damage, whereas downregulation of TXNIP enhances oxidative stress resistance and extends lifespan.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | T-CELL DEATH; LIFE-SPAN; DROSOPHILA-MELANOGASTER; STRESS; ACTIVATION; APOPTOSIS; MICE; OVEREXPRESSION; REDUCTASE; REPAIR; aging; DNA damage; oxidative stress; reactive oxygen species; thioredoxin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2020 07:28 |
| Last Modified: | 09 Mar 2020 07:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14280 |
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