Schaefer, Niklas and Proescholdt, Martin and Steinbach, Joachim P. and Weyerbrock, Astrid and Hau, Peter and Grauer, Oliver and Goldbrunner, Roland and Friedrich, Franziska and Rohde, veit and Ringel, Florian and Schlegel, Uwe and Sabel, Michael and Ronellenfitsch, Michael W. and Uhl, Martin and Grau, Stefan and Haenel, Mathias and Schnell, Oliver and Krex, Dietmar and Vajkoczy, Peter and Tabatabai, Ghazaleh and Mack, Frederic and Schaub, Christina and Tzaridis, Theophilos and Niessen, Michael and Kebir, Sied and Leutgeb, Barbara and Urbach, Horst and Belka, Claus and Stummer, Walter and Glas, Martin and Herrlinger, Ulrich (2018) Quality of life in the GLARIUS trial randomizing bevacizumab/ irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma. NEURO-ONCOLOGY, 20 (7). pp. 975-985. ISSN 1522-8517, 1523-5866
Full text not available from this repository. (Request a copy)Abstract
Background: The GLARIUS trial, which investigated the efficacy of bevacizumab (BEV)/irinotecan (IRI) compared with standard temozolomide in the first-line therapy of O-6-methylguanine-DNA methyltransferase (MGMT)nonmethylated glioblastoma, showed that progression-free survival was significantly prolonged by BEV/IRI, while overall survival was similar in both arms. The present report focuses on quality of life (QoL) and Karnofsky performance score (KPS) during the whole course of the disease. Methods: Patients (n = 170) received standard radiotherapy and were randomized (2: 1) for BEV/IRI or standard temozolomide. At least every 3 months KPS was determined and QoL was measured using the European Organisation for Research and Treatment of Cancer 30-item Core Quality of Life and 20-item Brain Neoplasm questionnaires. A generalized estimating equation (GEE) model evaluated differences in the course of QoL and KPS over time. Also, the time to first deterioration and the time to postprogression deterioration were analyzed separately. Results: In all dimensions of QoL and KPS, GEE analyses and time to first deterioration analyses did not detect significant differences between the treatment arms. At progression, 82% of patients receiving second-line therapy in the standard arm received BEV second-line therapy. For the dimensions of motor dysfunction and headaches, time to postprogression deterioration was prolonged in the standard arm receiving crossover second-line BEV in the vast majority of patients at the time of evaluation. Conclusions: GLARIUS did not find indications for a BEV-induced detrimental effect on QoL in first-line therapy of MGMT-nonmethylated GBM patients. Moreover, GLARIUS provided some indirect corroborative data supporting the notion that BEV may have beneficial effects upon QoL in relapsed GBM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MINI-MENTAL-STATE; ADJUVANT TEMOZOLOMIDE; PHASE-III; RADIOTHERAPY; CONCOMITANT; bevacizumab; crossover therapy; glioblastoma; progression; quality of life |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Mar 2020 08:22 |
| Last Modified: | 06 Mar 2020 08:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14332 |
Actions (login required)
 |
View Item |
