Buchtler, Simone and Grill, Alexandra and Hofmarksrichter, Stefanie and Stoeckert, Petra and Schiechl-Brachner, Gabriela and Gomez, Manuel Rodriguez and Neumayer, Sophia and Schmidbauer, Kathrin and Talke, Yvonne and Klinkhammer, Barbara M. and Boor, Peter and Medvinsky, Alexander and Renner, Kerstin and Castrop, Hayo and Mack, Matthias (2018) Cellular Origin and Functional Relevance of Collagen I Production in the Kidney. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 29 (7). pp. 1859-1873. ISSN 1046-6673, 1533-3450
Full text not available from this repository. (Request a copy)Abstract
Background Interstitial fibrosis is associated with chronic renal failure. In addition to fibroblasts, bone marrow-derived cells and tubular epithelial cells have the capacity to produce collagen. However, the amount of collagen produced by each of these cell types and the relevance of fibrosis to renal function are unclear. Methods We generated conditional cell type-specific collagen I knockout mice and used (reversible) unilateral ureteral obstruction and adenine-induced nephropathy to study renal fibrosis and function. Results In these mouse models, hematopoietic, bone marrow-derived cells contributed to 38%-50% of the overall deposition of collagen I in the kidney. The influence of fibrosis on renal function was dependent on the type of damage. In unilateral ureteral obstruction, collagen production by resident fibroblasts was essential to preserve renal function, whereas in the chronic model of adenine-induced nephropathy, collagen production was detrimental to renal function. Conclusions Our data show that hematopoietic cells are a major source of collagen and that antifibrotic therapies need to be carefully considered depending on the type of disease and the underlying cause of fibrosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TO-MESENCHYMAL TRANSITION; RENAL INTERSTITIAL FIBROSIS; MARROW-DERIVED CELLS; FIBROCYTE DIFFERENTIATION; URETERAL OBSTRUCTION; TRANSGENIC MICE; LUNG FIBROSIS; CYCLE ARREST; MOUSE MODEL; FIBROBLASTS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Feb 2020 14:00 |
| Last Modified: | 13 Feb 2020 14:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14336 |
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