Pathological Cerebrospinal Fluid Findings in Patients With Neuralgic Amyotrophy and Acute Hepatitis E Virus Infection

Fritz, Miriam and Berger, Benjamin and Schemmerer, Mathias and Endres, Dominique and Wenzel, Juergen J. and Stich, Oliver and Penning, Marcus (2018) Pathological Cerebrospinal Fluid Findings in Patients With Neuralgic Amyotrophy and Acute Hepatitis E Virus Infection. JOURNAL OF INFECTIOUS DISEASES, 217 (12). pp. 1897-1901. ISSN 0022-1899, 1537-6613

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Abstract

There is growing evidence that hepatitis E virus (HEV) infection can present with extrahepatic manifestations including neurological disorders. Among these, neuralgic amyotrophy (NA) has been reported to occur in some industrialized countries. We investigated 35 patients with NA and a control group for markers of HEV infection. Acute HEV infection was found in NA patients only and was associated with an inflammatory response in the central nervous system. Shedding of HEV RNA into the cerebrospinal fluid and intrathecal production of anti-HEV immunoglobulin M occurred in 1 patient, suggesting that HEV is neurotropic.

Item Type: Article
Uncontrolled Keywords: SEROPREVALENCE; GERMANY; hepatitis E virus; neuralgic amyotrophy; cerebrospinal fluid; control group
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Depositing User: Dr. Gernot Deinzer
Date Deposited: 09 Mar 2020 09:56
Last Modified: 09 Mar 2020 09:56
URI: https://pred.uni-regensburg.de/id/eprint/14398

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