Haimerl, Michael and Probst, Ute and Poelsterl, Stefanie and Beyer, Lukas and Fellner, Claudia and Selgrad, Michael and Hornung, Matthias and Stroszczynski, Christian and Wiggermann, Philipp (2018) Hepatobiliary MRI: Signal intensity based assessment of liver function correlated to C-13-Methacetin breath test. SCIENTIFIC REPORTS, 8: 9078. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Gadoxetic acid (Gd-EOB-DTPA) is a paramagnetic MRI contrast agent with raising popularity and has been used for evaluation of imaging-based liver function in recent years. In order to verify whether liver function as determined by real-time breath analysis using the intravenous administration of C-13-methacetin can be estimated quantitatively from Gd-EOB-DTPA-enhanced MRI using signal intensity (SI) values. 110 patients underwent Gd-EOB-DTPA-enhanced 3-T MRI and, for the evaluation of liver function, a C-13-methacetin breath test (C-13-MBT). SI values from before (SIpre) and 20 min after (SIpost) contrast media injection were acquired by T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat suppression. The relative enhancement (RE) between the plain and contrast-enhanced SI values was calculated and evaluated in a correlation analysis of C-13-MBT values to SIpost and RE to obtain a SI-based estimation of C-13-MBT values. The simple regression model showed a log-linear correlation of C-13-MBT values with SIpost and RE (p < 0.001). Stratified by 3 different categories of C-13-MBT readouts, there was a constant significant decrease in both SIpost (p <= 0.002) and RE (p <= 0.033) with increasing liver disease progression as assessed by the C-13-MBT. Liver function as determined using real-time C-13-methacetin breath analysis can be estimated quantitatively from GdEOB- DTPA-enhanced MRI using SI-based indices.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GD-EOB-DTPA; LIMAX TEST; ENHANCED MRI; HEPATIC-FUNCTION; CONTRAST AGENT; PARENCHYMAL ENHANCEMENT; CLINICAL-EVALUATION; FUNCTION CAPACITY; CIRRHOSIS; PHASE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2020 10:08 |
| Last Modified: | 09 Mar 2020 10:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14406 |
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