Peschel, G. and Moleda, L. and Baier, L. and Selgrad, M. and Schmid, S. and Scherer, M. N. and Mueller, M. and Weigand, K. (2018) Safety of Direct-Acting Antiviral Therapy Regarding Renal Function in Post-Liver Transplant Patients Infected with Hepatitis C Virus and a 100% 12-Week Sustained Virologic Response-A Single-Center Study. TRANSPLANTATION PROCEEDINGS, 50 (5). pp. 1444-1450. ISSN 0041-1345, 1873-2623
Full text not available from this repository. (Request a copy)Abstract
Background. Patients after liver transplantation (LT) with hepatitis C virus (HCV) infection often suffer from renal or hepatic impairment. Treating patients after LT with direct-acting antivirals (DAA) might result in decreasing renal function due to interaction of DAA and immunosuppressive therapy. In this single-center study we analyzed clinical parameters of 18 HCV-infected patients treated with DAA therapy after LT. Methods. The primary end points were change of renal function (glomerular filtration rate) and sustained virologic response 12 weeks after therapy (SVR12). For secondary end points, we investigated the influence of DAA therapy on transaminases, bilirubin, international normalized ratio, noninvasive fibrosis measurement, and Model for End-Stage Liver Disease (MELD) score. Results. Five out of 18 patients treated with DAA suffered from renal impairment stage 2, and 7 patients of renal impairment stage 3. Renal function at SVR12 was not influenced by preexisting renal impairment (P > .5), type of immunosuppressant (P > .5), or type of DAA regimen (P > .5). All patients reached SVR12. The levels of transaminases and bilirubin declined rapidly, as expected. Ten out of 18 patients already suffered from cirrhosis or liver fibrosis >F3 according to noninvasive measurement before initiation of treatment. Single-point acoustic radiation force impulse imaging improved in 9 patients (P = .012). In 7 patients, MELD score improved owing to the decrease of bilirubin levels. In 6 patients it worsened. Conclusions. DAA therapy in LT patients was effective and safe in this single-center real-life cohort. Renal function was not influenced by the administered drug combinations, even in patients with preexisting renal impairment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DRUG-DRUG INTERACTIONS; HCV INFECTION; SOFOSBUVIR; RIBAVIRIN; DACLATASVIR; RECIPIENTS; CYCLOSPORINE; SIMEPREVIR; TACROLIMUS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2020 08:42 |
| Last Modified: | 09 Mar 2020 08:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14451 |
Actions (login required)
 |
View Item |
