Rasche, Franz Maximilian and Rettig, Ronny and Frese, Thomas and Rasche, Wilma Gertrud and Barinka, Filip and Roesl, Guenter and Keller, Frieder and Lindner, Tom H. and Schneider, Jochen G. and Beige, Joachim and Ebert, Thomas and Schiekofer, Stephan (2018) The Pituitary-Thyroid Axis and Prolactin Secretion in Hemodialysis Patients in Two Endemic Regions of Eastern Germany Morphologic and laboratory abnormalities of the thyroid gland in CKD5D patients. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 126 (6). pp. 349-356. ISSN 0947-7349, 1439-3646
Full text not available from this repository. (Request a copy)Abstract
Introduction Endocrine disorders of the pituitary axes are frequent in patients with hemodialysis (CKD5D). The aim of this multicenter study (Leipzig (L), Quedlinburg and Blanken-burg in the Harz region (Hz)) in CKD5D patients was to evaluate influences of CKD5D related factors, morphological and biochemical parameters, and serum iodine and prolactin concentrations on the pituitary-thyroid axis. Patients and Methods 170 patients (L n = 58; Hz n = 112) were included in this prospective, non-interventional, crosssectional study. Mann-Whitney-U-test and bivariate correlation analyses with Spearman-Rho test (r correlation coefficient) were used in statistical analysis. Results TSH was higher in patients with prolactin concentrations > 370 mIU/l (p = 0.013), in patients with high flux membranes (p = 0.0013) and in patients with longer dialysis vintage (p = 0.04). Median iodine serum concentrations were slightly elevated in the Leipzig cohort (p = 0.001) and correlated with fT4 (p < 0.001, r = 0.43) and albumin (p = 0.001, r = 0.245) but not with morphological signs. Albumin was correlated with fT3 (p < 0.001, r = 0.339) and fT4 (p < 0.001, r = 0.421). Prolactin was correlated with residual excretion rate (p = 0.001, r = 0.303) and thyroid volume (p = 0.027, r = 0.217). Conclusions In the assessment of the thyroid status in CKD5D patients, the synopsis of the clinical and nutritional status, comorbidities, ultrasound of the thyroid gland and laboratory results is necessary for further intervention with hormone replacement. Standardized reference values of the pituitarythyroid axis should be critically evaluated and are still lacking in CKD5D.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC KIDNEY-DISEASE; CHRONIC-RENAL-FAILURE; SUBCLINICAL HYPOTHYROIDISM; IODINE; HYPERPROLACTINEMIA; THYROXINE; DIALYSIS; TRIIODOTHYRONINE; INSUFFICIENCY; THYROGLOBULIN; pituitary-thyroid axis; TSH; fT3; fT4; iodine serum concentration; prolactin; hemodialysis; goiter; nodule |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2020 11:14 |
| Last Modified: | 10 Mar 2020 11:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14484 |
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