Wege, Anja Kathrin (2018) Humanized Mouse Models for the Preclinical Assessment of Cancer Immunotherapy. BIODRUGS, 32 (3). pp. 245-266. ISSN 1173-8804, 1179-190X
Full text not available from this repository. (Request a copy)Abstract
Immunotherapy is one of the most exciting recent breakthroughs in the field of cancer treatment. Many different approaches are being developed and a number have already gained regulatory approval or are under investigation in clinical trials. However, learning from the past, preclinical animal models often insufficiently reflect the physiological situation in humans, which subsequently causes treatment failures in clinical trials. Due to species-specific differences in most parts of the immune system, the transfer of knowledge from preclinical studies to clinical trials is eminently challenging. Human tumor cell line-based or patient-derived xenografts in immunocompromised mice have been successfully applied in the preclinical testing of cytotoxic or molecularly targeted agents, but naturally these systems lack the human immune system counterpart. The co-transplantation of human peripheral blood mononuclear cells or hematopoietic stem cells is employed to overcome this limitation. This review summarizes some important aspects of the different available tumor xenograft mouse models, their history, and their implementation in drug development and personalized therapy. Moreover, recent progress, opportunities and limitations of different humanized mouse models will be discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE MYELOID-LEUKEMIA; NATURAL-KILLER-CELLS; INTERLEUKIN-2-RECEPTOR GAMMA-CHAIN; TUMOR-INFILTRATING LYMPHOCYTES; SUBRENAL CAPSULE XENOGRAFTS; SCID IL2R-GAMMA(NULL) MICE; CHIMERIC ANTIGEN RECEPTOR; HUMAN HEMATOPOIETIC NICHE; HUMAN IMMUNE-SYSTEM; MEMORY T-CELLS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 02 Jul 2020 05:40 |
| Last Modified: | 02 Jul 2020 05:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14503 |
Actions (login required)
 |
View Item |
