Schuessler, P. and Kluge, M. and Adamczyk, M. and Beitinger, M. E. and Beitinger, P. and Bleifuss, A. and Cordeiro, S. and Mattern, C. and Uhr, M. and Wetter, T. C. and Yassouridis, A. and Rupprecht, R. and Friess, E. and Steiger, A. (2018) Sleep after intranasal progesterone vs. zolpidem and placebo in postmenopausal women - A randomized, double-blind cross over study. PSYCHONEUROENDOCRINOLOGY, 92. pp. 81-86. ISSN 0306-4530,
Full text not available from this repository. (Request a copy)Abstract
Context The loss of progesterone during menopause is linked to sleep complaints of the affected women. Previously we demonstrated sleep promoting effects of oral progesterone replacement in postmenopausal women. The oral administration of progesterone, however, is compromised by individual differences in bioavailability and metabolism of the steroid. Objective: We compared the sleep-endocrine effects after intranasal progesterone (MPP22), zolpidem and placebo in healthy postmenopausal women. Design: This was a randomized double-blind cross-over study. Setting: German monocentric study Interventions: Subjects received in randomized order four treatments, 2 doses of intranasal progesterone (4.5 mg and 9 mg of MPP22), 10 mg of zolpidem and placebo. Outcome measures: Main outcome were conventional and quantitative sleep-EEG variables. Secondary outcomes were the subjective sleep variables and the sleep related concentrations of cortisol, growth hormone (GH), melatonin and progesterone. Results: Sleep promoting effects were found after the higher dosage of MPP22 and after zolpidem. Zolpidem prompted benzodiazepine-like effects on quantitative sleep EEG as expected, whereas no such changes were found after the two dosages of MP22. Nocturnal progesterone levels increased after 9.0 mg MPP22. No other changes of hormone secretion were found. Conclusions: Our study shows sleep promoting effects after intranasal progesterone. The spectral signature of intranasal progesterone did not resemble the sleep-EEG alterations induced by GABA active compounds. Progesterone levels were elevated after 9.0 mg MPP22. No other endocrine effects were observed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EVALUATION QUESTIONNAIRE; EEG; REPLACEMENT; MECHANISMS; MENOPAUSE; DELIVERY; SPECTRA; CYCLE; Progesterone; Sleep; Menopause; Intranasal; MPP22; Zolpidem |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2020 13:38 |
| Last Modified: | 10 Mar 2020 13:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14525 |
Actions (login required)
 |
View Item |
