Weigand, Kilian and Weigand, Kurt and Schemmerer, Mathias and Mueller, Martina and Wenzel, Juergen J. (2018) Hepatitis E Seroprevalence and Genotyping in a Cohort of Wild Boars in Southern Germany and Eastern Alsace. FOOD AND ENVIRONMENTAL VIROLOGY, 10 (2). pp. 167-175. ISSN 1867-0334, 1867-0342
Full text not available from this repository. (Request a copy)Abstract
In the last few years it has been realized that the hepatitis E virus (HEV) is endemic in most industrialized countries and that it is a zoonotic disease. Potential reservoirs for HEV have been identified to be wild boars and deers, but HEV has also been found in domestic pigs and other animals. Due to the probable spread of the virus via contaminated food or contact to infected animals, HEV antibodies are present in more than 16% of the German adult population and rates are increasing with age. We collected blood from 104 wild boars in southern Germany and the border region of Alsace. We found an anti-HEV seroprevalence of 11.5% in our cohort, using ELISA. Furthermore, we observed active infection in 3.85% of the animals by positive HEV PCR in the sera of the boars. In our cohort, no regional differences of seroprevalence or active infection were seen. Sequencing revealed rather close homology of some detected HEV sequences to genotypes isolated from patients in Germany. Hence wild boars are a potential source of HEV infection in Middle Europe and the rate of infectious animals is quite high.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | E VIRUS-INFECTION; ORGAN TRANSPLANT RECIPIENTS; NON-B HEPATITIS; ANTIBODY PREVALENCE; BLOOD-DONORS; PHYLOGENETIC ANALYSIS; SOUTHEASTERN GERMANY; NON-A; TRANSMISSION; DISEASE; Hepatitis E; Genotyping; Seroprevalence; Wild boar |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2020 13:48 |
| Last Modified: | 10 Mar 2020 13:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14539 |
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