Ignatov, Tanja and Eggemann, Holm and Burger, Elke and Ortmann, Olaf and Costa, Serban Dan and Ignatov, Atanas (2018) Ovarian metastasis in patients with endometrial cancer: risk factors and impact on survival. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 144 (6). pp. 1103-1107. ISSN 0171-5216, 1432-1335
Full text not available from this repository. (Request a copy)Abstract
Background Oophorectomy is generally performed in patients with endometrial cancer despite the rate of ovarian metastasis being relatively low. Patients and methods A multicenter retrospective registry-based study was performed in 2329 patients with endometrial cancer. The outcome measures were the incidence of ovarian metastasis and the impact on overall survival. Results Median follow-up was performed at 84 months. A total of 2158 women were eligible for analysis, of which 131 (6.1%) had ovarian metastasis. Women with ovarian metastasis were more likely to have > 50% myometrial invasion, undifferentiated nonendometrioid tumors, and lymph and vascular space invasion. The presence of < 50% myometrial invasion, endometrioid histology, well-differentiated cancer, and negative lymph and vascular space invasion were associated with a very low rate (0.5%) of ovarian metastasis. Notably, after matching for tumor histology and grade, myometrial invasion, and lymph and vascular space invasion, ovarian metastasis was not associated with a reduced median overall survival. Conclusions Ovarian preservation should be offered to premenopausal women with endometrial cancer in whom myometrial invasion is less than 50%, the histological type is endometrioid and well-differentiated, and lymph and vascular space invasion is not involved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WOMEN; PRESERVATION; CARCINOMA; Endometrial cancer; Ovarian; Metastasis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2020 13:49 |
| Last Modified: | 10 Mar 2020 13:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14541 |
Actions (login required)
 |
View Item |
