Dreher, Michael and Krueger, Stefan and Schulze-Olden, Susanne and Keszei, Andras and Storre, Jan Hendrik and Woehrle, Holger and Arzt, Michael and Mueller, Tobias (2018) Sleep-disordered breathing in patients with newly diagnosed lung cancer. BMC PULMONARY MEDICINE, 18: 72. ISSN 1471-2466,
Full text not available from this repository. (Request a copy)Abstract
Background: There are currently no data on the prevalence of sleep-disordered breathing (SDB) in patients with newly-diagnosed lung cancer. This might be of interest given that SDB is associated with increased cancer incidence and mortality. Furthermore, intermittent hypoxia has been linked with tumor growth and progression. The aim of the current study was to investigate the prevalence of SDB in patients with newly-diagnosed lung cancer. Methods: Patients with newly-diagnosed lung cancer from three centers in Germany were screened for SDB using a two-channel screening system (ApneaLink (TM)) SDB was defined as an apnea-hypopnea index of >5/h, and was classified as mild if the AHI was 5-15/h whereas an AHI >= 15/h was classified as severe SDB. The presence of SDB-related symptoms was assessed using the Epworth Sleepiness Scale (ESS) and the Pittsburgh Sleep Quality Index (PSQI). Results: A total of 100 patients were included. The overall prevalence of SDB was 49%; 32 patients (32%) had mild SDB with a median AHI of 7.7/h (quartile [Q, 5.4/h, Q3 10.4/h]) and a median oxygen desaturation index of 8.5 [Q1 4.2/h; Q3 13.4/h] and seventeen patients (17%) had moderate to severe SDB with a median AHI of 25.2 [Q1 18/h, Q3 45.5/h] and a median oxygen desaturation index of 20.6/h [Q, 9.6/h, Q3 36.6/h]. Patients with moderate to severe SDB had mild daytime sleepiness (ESS score 8.24 +/- 3.96 vs. 5.74 +/- 3.53 in those without SDB vs. 6.22 +/- 2.72 in those with mild SDB; p = 0.0343). The PSQI did not differ significantly between the three groups (p = 0.1137). Conclusions: This study showed a high prevalence of SDB in patients with newly-diagnosed lung cancer. In these patients SDB was associated with intermittent hypoxia and increased daytime sleepiness. Additional research is needed to determine whether SDB influences prognosis and morbidity in patients with lung cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECORDING DEVICE; APNEA; ASSOCIATION; PREVALENCE; APNEALINK(TM); METAANALYSIS; COHORT; ADULTS; Lung neoplasm; sleep-related disorders; sleep-related hypoxaemia; Lung cancer; Sleep apnea; Sleep disorders |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2020 08:26 |
| Last Modified: | 06 Apr 2020 05:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14574 |
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