Haberl, Elisabeth M. and Pohl, Rebekka and Rein-Fischboeck, Lisa and Feder, Susanne and Sinal, Christopher J. and Buechler, Christa (2018) Chemerin in a Mouse Model of Non-alcoholic Steatohepatitis and Hepatocarcinogenesis. ANTICANCER RESEARCH, 38 (5). pp. 2649-2657. ISSN 0250-7005, 1791-7530
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Background/Aim: Non-alcoholic steatohepatitis (NASH) is a risk factor for hepatocellular carcinoma (HCC). The adipokine chemerin protects from HCC and is reduced in human HCC. In this study, chemerin expression was analyzed in a murine model of NASH-HCC. Materials and Methods: Serum and hepatic chemerin, and ex vivo chemerin receptor activation were monitored in NASH and NASH-HCC in mice fed a low-methionine diet deficient in choline after initiation of tumors by injection of diethylnitrosamine. Results: In non-tumorous liver tissues, the extent of hepatic steatosis, and the levels of proteins regulating hepatic lipids and liver fibrosis were similar in NASH and NASH-associated HCC. Systemic and hepatic chemerin, and chemerin receptor activation were not changed in HCC. Liver tumors only developed in diethylnitrosamine-injected mice and their number was increased in NASH. Chemerin protein was induced in liver in NASH, but was unchanged in HCC tissues. Conclusion: Hepatic and serum chemerin and ex vivo analyzed chemerin receptor activation do not differ in murine NASH-associated HCC when compared to NASH. Hepatic tumors still develop despite high endogenous levels of serum and liver chemerin protein.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHOLINE-DEFICIENT DIET; FATTY LIVER-DISEASE; MESSENGER-RNA EXPRESSION; HEPATOCELLULAR-CARCINOMA; SERUM CHEMERIN; OBESE MICE; EX-VIVO; CMKLR1; ADIPONECTIN; METABOLISM; Liver tumor; NASH; chemerin activity; CMKLR1 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Feb 2020 13:55 |
| Last Modified: | 17 Feb 2020 13:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14619 |
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