Schaible, H-G. and Chang, H. -D. and Graessel, S. and Haibel, H. and Hess, A. and Kamradt, T. and Radbruch, A. and Schett, G. and Stein, C. and Straub, R. H. (2018) Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases. ZEITSCHRIFT FUR RHEUMATOLOGIE, 77. pp. 24-30. ISSN 0340-1855, 1435-1250
Full text not available from this repository. (Request a copy)Abstract
The research consortium Neuroimmunology and Pain (Neuroimpa) explores the importance of the relationships between the immune system and the nervous system in musculoskeletal diseases for the generation of pain and for the course of fracture healing and arthritis. The spectrum of methods includes analyses at the single cell level, in vivo models of arthritis and fracture healing, imaging studies on brain function in animals and humans and analysis of data from patients. Proinflammatory cytokines significantly contribute to the generation of joint pain through neuronal cytokine receptors. Immune cells release opioid peptides which activate opioid receptors at peripheral nociceptors and thereby evoke hypoalgesia. The formation of new bone after fractures is significantly supported by the nervous system. The sympathetic nervous system promotes the development of immune-mediated arthritis. The studies show a significant analgesic potential of the neutralization of proinflammatory cytokines and of opioids which selectively inhibit peripheral neurons. Furthermore, they show that the modulation of neuronal mechanisms can beneficially influence the course of musculoskeletal diseases. Interventions in the interactions between the immune system and the nervous system hold a great therapeutic potential for the treatment of musculoskeletal diseases and pain.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYMPATHETIC-NERVE FIBERS; ARTHRITIC PAIN; CHRONIC INFLAMMATION; SENSORY NEURONS; LYMPH-NODES; BRAIN; INVOLVEMENT; RECEPTORS; BLOCKADE; HYPEREXCITABILITY; Immune system; Nervous system; Musculoskeletal diseases; Opioids; Proinflammatory cytokines |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2020 13:34 |
| Last Modified: | 23 Mar 2020 13:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14669 |
Actions (login required)
 |
View Item |
