Scharl, Sophia and Papathemelis, Thomas and Kronberger, Karin and Gerken, Michael and Scharl, Anton and Koelbl, Oliver and Klinkhammer-Schalke, Monika (2018) Does post-operative radiochemotherapy improve survival in high-grade endometrial cancer patients? Results of a population-based cohort analysis of a cancer registry. ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 297 (5). pp. 1245-1253. ISSN 0932-0067, 1432-0711
Full text not available from this repository. (Request a copy)Abstract
Adjuvant treatment of high-grade endometrial cancer varies greatly due to the lack of definitive results from controlled randomized trials on the subject. In a retrospective study, we sought to investigate the influence of post-operative radio-, chemo, and radiochemotherapy on survival time and recurrence rates among high-grade endometrial cancer patients. 284 high-grade endometrial cancer patients (FIGOI-III, or unknown classification) diagnosed between 1998 and 2015 were retrospectively analyzed. All patients underwent surgery. Overall survival (OS), recurrence-free survival (RFS), and recurrence rates were compared for post-operative treatment modalities of radiotherapy alone (RT), chemotherapy alone (CTX), radiochemotherapy (RCT), and observation (OBS). Post-operative RCT and RT resulted in a significantly improved 5-year OS of 94.1% (HR 0.104, CI 0.013-0.809) and 62.1% (HR 0.615, CI 0.390-0.969), respectively, compared to 43.6% for OBS. CTX did not significantly improve OS leading to a 5-year OS of 56.5% (HR 0.783, CI 0.224-2.740). 5-year recurrence rate was lowest for patients treated with RCT (5.3%). 5-year RFS was 94.1% for the RCT group and proved to be significantly superior to 58.8% for RT (HR 9.034, CI 1.184-68.948), 56% for CTX (HR 12.738, CI 1.337-121.346), and 37.4% for OBS (HR 16.407, CI 2.127-126.575), respectively. In comparison with OBS, RT alone resulted in a significant improvement in RFS (HR 0.551, CI 0.354-0.856). Our retrospective population-based study indicates a survival benefit from treating high-grade endometrial cancer with post-operative RCT. Randomized controlled trials are needed to minimize potential confounding parameters and further clarify the subject.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTERNAL-BEAM RADIOTHERAPY; ADJUVANT CHEMOTHERAPY; OPEN-LABEL; CARCINOMA; OUTCOMES; TRIAL; Endometrial cancer; Radiotherapy; Chemotherapy; Adjuvant treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2020 13:51 |
| Last Modified: | 19 Mar 2020 13:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14684 |
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