Menon, Rohit and Grund, Thomas and Zoicas, Iulia and Althammer, Ferdinand and Fiedler, Dominik and Biermeier, Verena and Bosch, Oliver J. and Hiraoka, Yuichi and Nishimori, Katsuhiko and Eliava, Marina and Grinevich, Valery and Neumann, Inga D. (2018) Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation. CURRENT BIOLOGY, 28 (7). 1066-+. ISSN 0960-9822, 1879-0445
Full text not available from this repository. (Request a copy)Abstract
Oxytocin (OXT)-mediated behavioral responses to social and stressful cues have extensively been studied in male rodents. Here, we investigated the capacity of brain OXT receptor (OXTR) signaling in the lateral septum (LS) to prevent social fear expression in female mice using the social-fear-conditioning paradigm. Utilizing the activated OXT system during lactation, we show that lactating mice did not express fear 24 hr after social fear conditioning. Supporting the role of OXTR signaling in the LS in attenuation of social fear, synthetic OXT infusion or overexpression of OXTR in the LS diminished social fear expression, whereas constitutive OXTR knockout severely impaired social fear extinction in virgin mice. Subsequently, both pharmacological blockade of local OXTRs in the LS and chemogenetic silencing of supraoptic nucleus OXTergic afferents to the LS increased social fear expression in lactating mice. Hence, LS-projecting OXT neurons suppress social fear in female mice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECEPTOR EXPRESSION; PREFRONTAL CORTEX; BRAIN OXYTOCIN; PAIN THRESHOLD; ANXIETY; MICE; RATS; VASOPRESSIN; AGGRESSION; BEHAVIOR; |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2020 13:45 |
| Last Modified: | 10 Mar 2020 13:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/14752 |
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